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@ARTICLE{Zips:904338,
      author       = {Zips, Sabine and Hiendlmeier, Lukas and Weiß, Lennart
                      Jakob Konstantin and Url, Heike and Teshima, Tetsuhiko F.
                      and Schmid, Richard and Eblenkamp, Markus and Mela, Petra
                      and Wolfrum, Bernhard},
      title        = {{B}iocompatible, {F}lexible, and {O}xygen-{P}ermeable
                      {S}ilicone-{H}ydrogel {M}aterial for {S}tereolithographic
                      {P}rinting of {M}icrofluidic {L}ab-{O}n-{A}-{C}hip and
                      {C}ell-{C}ulture {D}evices},
      journal      = {ACS applied polymer materials},
      volume       = {3},
      number       = {1},
      issn         = {2637-6105},
      address      = {Washington, DC},
      publisher    = {ACS Publications},
      reportid     = {FZJ-2021-05908},
      pages        = {243 - 258},
      year         = {2021},
      abstract     = {We present a photocurable, biocompatible, and flexible
                      silicone-hydrogel hybrid material for stereolithographic
                      (SLA) printing of biomedical devices. The silicone-hydrogel
                      polymer is similar to mixtures used for contact lenses. It
                      is flexible and stretchable with a Young’s modulus of 78
                      MPa and a maximum elongation at break of $51\%,$ shows a low
                      degree of swelling $(<4\%$ v/v) in water, and can be bonded
                      easily to flat glass substrates via a surface-modification
                      method. The in vitro cytotoxicity of the material is
                      assessed with a WST-8 cell viability assay using five
                      different cell lines: HT1080, L929, and Hs27 fibroblasts,
                      cardiomyocyte-like HL-1 cells, and neuronal-phenotype PC-12
                      cells. On this account, the silicone-hydrogel polymer is
                      compared to several other common SLA printing materials used
                      for cell-culture applications and polydimethylsiloxane
                      (PDMS). A simple extraction step in water is sufficient for
                      reaching biocompatibility of the material with respect to
                      the tested cell types. The oxygen permeability of the
                      silicone-hydrogel material is investigated and compared to
                      that of PDMS, Medicalprint clear—a commercial resin for
                      medical products, and a short-chain hydrogel-based resin. As
                      a proof of concept, we demonstrate a 3D-printed microfluidic
                      device with integrated valves and mixers. Furthermore, we
                      show a printed culture chamber for analyzing signal
                      propagation in HL-1 cardiomyocyte cell networks. Ca2+
                      imaging is used to observe the signal propagation through
                      the cardiac cell layers grown in the microchannels. The
                      cells are shown to maintain normal electrophysiological
                      activity within the printed chambers. Overall, the
                      biocompatible silicone-hydrogel material will be an
                      advancement for SLA printing in cell-culture and
                      microfluidic lab-on-a-chip applications.},
      cin          = {IBI-3},
      ddc          = {540},
      cid          = {I:(DE-Juel1)IBI-3-20200312},
      pnm          = {5244 - Information Processing in Neuronal Networks
                      (POF4-524)},
      pid          = {G:(DE-HGF)POF4-5244},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000609249200027},
      doi          = {10.1021/acsapm.0c01071},
      url          = {https://juser.fz-juelich.de/record/904338},
}