% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Wolf:904341,
      author       = {Wolf, Nikolaus and Rai, Pratika and Glass, Manuel and
                      Milos, Frano and Maybeck, Vanessa and Offenhäusser, Andreas
                      and Wördenweber, Roger},
      title        = {{M}echanical and {E}lectronic {C}ell–{C}hip {I}nteraction
                      of {APTES}-{F}unctionalized {N}euroelectronic {I}nterfaces},
      journal      = {ACS applied bio materials},
      volume       = {4},
      number       = {8},
      issn         = {2576-6422},
      address      = {Washington, DC},
      publisher    = {ACS Publications},
      reportid     = {FZJ-2021-05911},
      pages        = {6326 - 6337},
      year         = {2021},
      abstract     = {In this work, we analyze the impact of a chip coating with
                      a self-assembled monolayer (SAM) of
                      (3-aminopropyl)triethoxysilane (APTES) on the electronic and
                      mechanical properties of neuroelectronic interfaces. We show
                      that the large signal transfer, which has been observed for
                      these interfaces, is most likely a consequence of the strong
                      mechanical coupling between cells and substrate. On the one
                      hand, we demonstrate that the impedance of the interface
                      between Pt electrodes and an electrolyte is slightly reduced
                      by the APTES SAM. However, this reduction of approximately
                      $13\%$ is definitely not sufficient to explain the large
                      signal transfer of APTES coated electrodes demonstrated
                      previously. On the other hand, the APTES coating leads to a
                      stronger mechanical clamping of the cells, which is visible
                      in microscopic images of the cell development of
                      APTES-coated substrates. This stronger mechanical
                      interaction is most likely caused by the positively charged
                      amino functional group of the APTES SAM. It seems to lead to
                      a smaller cleft between substrate and cells and, thus, to
                      reduced losses of the cell’s action potential signal at
                      the electrode. The disadvantage of this tight binding of the
                      cells to the rigid, planar substrate seems to be the short
                      lifetime of the cells. In our case the density of living
                      cells starts to decrease together with the visual
                      deformation of the cells typically at DIV 9. Solutions for
                      this problem might be the use of soft substrates and/or the
                      replacement of the short APTES molecules with larger
                      molecules or molecular multilayers.},
      cin          = {IBI-3},
      ddc          = {570},
      cid          = {I:(DE-Juel1)IBI-3-20200312},
      pnm          = {5244 - Information Processing in Neuronal Networks
                      (POF4-524)},
      pid          = {G:(DE-HGF)POF4-5244},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {35006867},
      UT           = {WOS:000687042400043},
      doi          = {10.1021/acsabm.1c00576},
      url          = {https://juser.fz-juelich.de/record/904341},
}