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@ARTICLE{FigueroaMiranda:904346,
      author       = {Figueroa-Miranda, Gabriela and Chen, Song and Neis, Marc
                      and Zhou, Lei and Zhang, Yuting and Lo, Young and Tanner,
                      Julian Alexander and Kreidenweiss, Andrea and Offenhäusser,
                      Andreas and Mayer, Dirk},
      title        = {{M}ulti-target electrochemical malaria aptasensor on
                      flexible multielectrode arrays for detection in malaria
                      parasite blood samples},
      journal      = {Sensors and actuators / B},
      volume       = {349},
      issn         = {0925-4005},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {FZJ-2021-05916},
      pages        = {130812 -},
      year         = {2021},
      abstract     = {Despite all efforts, malaria is still highly prevalent in
                      tropical and developing countries. The “test, treat and
                      track” policy of the World Health Organization (WHO)
                      demands the development of affordable and highly sensitive
                      malaria tests that discriminate between the two common
                      malaria parasites, Plasmodium falciparum and Plasmodium
                      vivax, to guide appropriate treatments. In response, we
                      developed a flexible and disposable multielectrode array
                      utilized as electrochemical malaria aptasensor. This
                      multi-target aptasensor was modified by four different
                      aptamer receptors, discriminating between P. falciparum and
                      P. vivax infections via Plasmodium lactate dehydrogenase,
                      expressed by both species, and histidine-rich protein 2,
                      exclusively expressed by P. falciparum. The multi-target
                      aptasensor detection was tested in blood samples spiked with
                      target proteins, whole human blood spiked with P.
                      falciparum, and P. falciparum in vitro cultures. A rigorous
                      analysis revealed sensitivities of $>75.0\%$ for $0.001\%$
                      parasitemia (50 parasites/µL) and a logic gate-based
                      discrimination of Plasmodium infections, overcoming WHO
                      standards. A cost analysis further substantiated the
                      applicability of this multi-target aptasensor as a
                      disposable point-of-care test for remote areas dealing with
                      prevalent malaria parasite infections.},
      cin          = {IBI-3},
      ddc          = {620},
      cid          = {I:(DE-Juel1)IBI-3-20200312},
      pnm          = {5241 - Molecular Information Processing in Cellular Systems
                      (POF4-524)},
      pid          = {G:(DE-HGF)POF4-5241},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000707315100008},
      doi          = {10.1016/j.snb.2021.130812},
      url          = {https://juser.fz-juelich.de/record/904346},
}