TY  - JOUR
AU  - Grob, Leroy
AU  - Rinklin, Philipp
AU  - Zips, Sabine
AU  - Mayer, Dirk
AU  - Weidlich, Sabrina
AU  - Terkan, Korkut
AU  - Weiß, Lennart J. K.
AU  - Adly, Nouran
AU  - Offenhäusser, Andreas
AU  - Wolfrum, Bernhard
TI  - Inkjet-Printed and Electroplated 3D Electrodes for Recording Extracellular Signals in Cell Culture
JO  - Sensors
VL  - 21
IS  - 12
SN  - 1424-8220
CY  - Basel
PB  - MDPI
M1  - FZJ-2021-05917
SP  - 3981 -
PY  - 2021
AB  - Recent investigations into cardiac or nervous tissues call for systems that are able to electrically record in 3D as opposed to 2D. Typically, challenging microfabrication steps are required to produce 3D microelectrode arrays capable of recording at the desired position within the tissue of interest. As an alternative, additive manufacturing is becoming a versatile platform for rapidly prototyping novel sensors with flexible geometric design. In this work, 3D MEAs for cell-culture applications were fabricated using a piezoelectric inkjet printer. The aspect ratio and height of the printed 3D electrodes were user-defined by adjusting the number of deposited droplets of silver nanoparticle ink along with a continuous printing method and an appropriate drop-to-drop delay. The Ag 3D MEAs were later electroplated with Au and Pt in order to reduce leakage of potentially cytotoxic silver ions into the cellular medium. The functionality of the array was confirmed using impedance spectroscopy, cyclic voltammetry, and recordings of extracellular potentials from cardiomyocyte-like HL-1 cell
LB  - PUB:(DE-HGF)16
C6  - 34207725
UR  - <Go to ISI:>//WOS:000667881000001
DO  - DOI:10.3390/s21123981
UR  - https://juser.fz-juelich.de/record/904347
ER  -