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@ARTICLE{Jablonski:904349,
      author       = {Jablonski, Melanie and Poghossian, Arshak and Keusgen,
                      Michael and Wege, Christina and Schöning, Michael J.},
      title        = {{D}etection of plant virus particles with a capacitive
                      field-effect sensor},
      journal      = {Analytical and bioanalytical chemistry},
      volume       = {413},
      number       = {22},
      issn         = {0016-1152},
      address      = {Heidelberg},
      publisher    = {Springer},
      reportid     = {FZJ-2021-05919},
      pages        = {5669 - 5678},
      year         = {2021},
      abstract     = {Plant viruses are major contributors to crop losses and
                      induce high economic costs worldwide. For reliable, on-site
                      and early detection of plant viral diseases, portable
                      biosensors are of great interest. In this study, a
                      field-effect SiO2-gate electrolyte-insulator-semiconductor
                      (EIS) sensor was utilized for the label-free electrostatic
                      detection of tobacco mosaic virus (TMV) particles as a model
                      plant pathogen. The capacitive EIS sensor has been
                      characterized regarding its TMV sensitivity by means of
                      constant-capacitance method. The EIS sensor was able to
                      detect biotinylated TMV particles from a solution with a TMV
                      concentration as low as 0.025 nM. A good correlation between
                      the registered EIS sensor signal and the density of adsorbed
                      TMV particles assessed from scanning electron microscopy
                      images of the SiO2-gate chip surface was observed.
                      Additionally, the isoelectric point of the biotinylated TMV
                      particles was determined via zeta potential measurements and
                      the influence of ionic strength of the measurement solution
                      on the TMV-modified EIS sensor signal has been studied.},
      cin          = {IBI-3},
      cid          = {I:(DE-Juel1)IBI-3-20200312},
      pnm          = {5241 - Molecular Information Processing in Cellular Systems
                      (POF4-524)},
      pid          = {G:(DE-HGF)POF4-5241},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {34244834},
      UT           = {WOS:000671514500002},
      doi          = {10.1007/s00216-021-03448-8},
      url          = {https://juser.fz-juelich.de/record/904349},
}