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@ARTICLE{Molinnus:904354,
      author       = {Molinnus, Denise and Drinic, Aleksander and Iken, Heiko and
                      Kröger, Nadja and Zinser, Max and Smeets, Ralf and Köpf,
                      Marius and Kopp, Alexander and Schöning, Michael J.},
      title        = {{T}owards a flexible electrochemical biosensor fabricated
                      from biocompatible {B}ombyx mori silk},
      journal      = {Biosensors and bioelectronics},
      volume       = {183},
      issn         = {0956-5663},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {FZJ-2021-05924},
      pages        = {113204 -},
      year         = {2021},
      abstract     = {In modern days, there is an increasing relevance of and
                      demand for flexible and biocompatible sensors for in-vivo
                      and epidermal applications. One promising strategy is the
                      implementation of biological (natural) polymers, which offer
                      new opportunities for flexible biosensor devices due to
                      their high biocompatibility and adjustable biodegradability.
                      As a proof-of-concept experiment, a biosensor was fabricated
                      by combining thin- (for Pt working- and counter electrode)
                      and thick-film (for Ag/AgCl quasi-reference electrode)
                      technologies: The biosensor consists of a fully bio-based
                      and biodegradable fibroin substrate derived from silk
                      fibroin of the silkworm Bombyx mori combined with
                      immobilized enzyme glucose oxidase. The flexible glucose
                      biosensor is encapsulated by a biocompatible silicon rubber
                      which is certificated for a safe use onto human skin.
                      Characterization of the sensor set-up is exemplarily
                      demonstrated by glucose measurements in buffer and Ringer's
                      solution, while the stability of the quasi-reference
                      electrode has been investigated versus a commercial Ag/AgCl
                      reference electrode. Repeated bending studies validated the
                      mechanical properties of the electrode structures. The
                      cross-sensitivity of the biosensor against ascorbic acid,
                      noradrenaline and adrenaline was investigated, too.
                      Additionally, biocompatibility and degradation tests of the
                      silk fibroin with and without thin-film platinum electrodes
                      were carried out.},
      cin          = {IBI-3},
      ddc          = {610},
      cid          = {I:(DE-Juel1)IBI-3-20200312},
      pnm          = {5241 - Molecular Information Processing in Cellular Systems
                      (POF4-524)},
      pid          = {G:(DE-HGF)POF4-5241},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {33836429},
      UT           = {WOS:000647774000001},
      doi          = {10.1016/j.bios.2021.113204},
      url          = {https://juser.fz-juelich.de/record/904354},
}