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@ARTICLE{Kang:904362,
      author       = {Kang, Kyongok and Ma, Yue and Sadakane, Koichiro},
      title        = {{D}irect visualization of local activities of long {DNA}
                      strands via image–time correlation},
      journal      = {European biophysics journal},
      volume       = {50},
      number       = {8},
      issn         = {0175-7571},
      address      = {New York},
      publisher    = {Springer},
      reportid     = {FZJ-2021-05932},
      pages        = {1139 - 1155},
      year         = {2021},
      abstract     = {Bacteriophages with long DNA genomes are of interest due to
                      their diverse mutations dependent on environmental factors.
                      By lowering the ionic strength of a hydrophobic (PPh4Cl)
                      antagonistic salt (at 1 mM), single long T4 DNA strand
                      fluctuations were clearly observed, while condensed states
                      of T4 DNA globules were formed above 5–10 mM salt. These
                      long DNA strands were treated with fluorescently labeled
                      probes, for which photo bleaching is often unavoidable over
                      a short time of measurement. In addition, long (few tens of
                      μm) length scales are required to have larger fields of
                      view for better sampling, with shorter temporal resolutions.
                      Thus, an optimization between length and time is crucial to
                      obtain useful information. To facilitate the challenge of
                      detecting large biomacromolecules, we here introduce an
                      effective method of live image data analysis for direct
                      visualization and quantification of local thermal
                      fluctuations. The motions of various conformations for the
                      motile long DNA strands were examined for the single- and
                      multi-T4 DNA strands. We find that the unique correlation
                      functions exhibit a relatively high-frequency oscillatory
                      behavior superimposed on the overall slower decay of the
                      correlation function with a splitting of amplitudes deriving
                      from local activities of the long DNA strands. This work
                      shows not only the usefulness of an image–time correlation
                      for analyzing large biomacromolecules, but also provides
                      insight into the effects of a hydrophobic antagonistic salt
                      on active T4 bacteriophage long DNA strands, including
                      thermal translocations in their electrostatic interactions.},
      cin          = {IBI-4},
      ddc          = {570},
      cid          = {I:(DE-Juel1)IBI-4-20200312},
      pnm          = {5241 - Molecular Information Processing in Cellular Systems
                      (POF4-524)},
      pid          = {G:(DE-HGF)POF4-5241},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:34499211},
      UT           = {WOS:000694572400001},
      doi          = {10.1007/s00249-021-01570-0},
      url          = {https://juser.fz-juelich.de/record/904362},
}