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@ARTICLE{Ophey:904370,
      author       = {Ophey, Anja and Krohm, Fabian and Kalbe, Elke and Greuel,
                      Andrea and Drzezga, Alexander and Tittgemeyer, Marc and
                      Timmermann, Lars and Jessen, Frank and Eggers, Carsten and
                      Maier, Franziska},
      title        = {{N}eural correlates and predictors of subjective cognitive
                      decline in patients with {P}arkinson’s disease},
      journal      = {Neurological sciences},
      volume       = {43},
      issn         = {0392-0461},
      address      = {Milano},
      publisher    = {Springer},
      reportid     = {FZJ-2021-05940},
      pages        = {3153–3163},
      year         = {2022},
      abstract     = {Background: Subjective cognitive decline (SCD) may occur
                      very early in the course of Parkinson's disease (PD) before
                      the onset of objective cognitive decline. Data on neural
                      correlates and determinants of SCD in PD are rare.Objective:
                      The aim of the present study was to identify neural
                      correlates as well as sociodemographic, clinical, and
                      neuropsychological predictors of SCD in patients with
                      PD.Methods: We retrospectively analyzed 30 patients with PD
                      without cognitive impairment $(23\%$ female, 66.90 ± 7.20
                      years, UPDRS-III: 19.83 ± 9.29), of which n = 12 patients
                      were classified as having no SCD (control group, PD-CG) and
                      n = 18 as having SCD (PD-SCD). Neuropsychological testing
                      and 18-fluoro-2-deoxyglucose positron emission tomography
                      (FDG-PET) were conducted. SCD was assessed using a
                      questionnaire covering multiple cognitive domains.Results:
                      SCD subscores differed significantly between PD-CG and
                      PD-SCD and correlated significantly with other scales
                      measuring related concepts. FDG-PET whole-brain voxel-wise
                      regression analysis revealed hypometabolism in middle
                      frontal, middle temporal, and occipital areas, and the
                      angular gyrus as neural correlates of SCD in PD. Next to
                      this hypometabolism, depressive symptoms were an independent
                      significant determinant of SCD in a stepwise regression
                      analysis (adjusted R2 = $50.3\%).Conclusion:$ This study
                      strengthens the hypothesis of SCD being an early
                      manifestation of future cognitive decline in PD and, more
                      generally, early pathological changes in PD. The early
                      identification of the vulnerability for future cognitive
                      decline constitutes the basis for successful prevention and
                      delay of this non-motor symptom.Keywords: Neural correlates;
                      Parkinson disease; Positron emission tomography; Predictors;
                      Subjective cognitive decline.},
      cin          = {INM-2},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-2-20090406},
      pnm          = {5252 - Brain Dysfunction and Plasticity (POF4-525) / 5253 -
                      Neuroimaging (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5252 / G:(DE-HGF)POF4-5253},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {34820745},
      UT           = {WOS:000722113800002},
      doi          = {10.1007/s10072-021-05734-w},
      url          = {https://juser.fz-juelich.de/record/904370},
}