%0 Journal Article
%A Palleis, Carla
%A Brendel, Matthias
%A Finze, Anika
%A Weidinger, Endy
%A Bötzel, Kai
%A Danek, Adrian
%A Beyer, Leonie
%A Nitschmann, Alexander
%A Kern, Maike
%A Biechele, Gloria
%A Rauchmann, Boris-Stephan
%A Häckert, Jan
%A Höllerhage, Matthias
%A Stephens, Andrew W.
%A Drzezga, Alexander
%A Eimeren, Thilo
%A Villemagne, Victor L.
%A Schildan, Andreas
%A Barthel, Henryk
%A Patt, Marianne
%A Sabri, Osama
%A Bartenstein, Peter
%A Perneczky, Robert
%A Haass, Christian
%A Levin, Johannes
%A Höglinger, Günter U.
%T Cortical [18F]PI‐2620 Binding Differentiates Corticobasal Syndrome Subtypes
%J Movement disorders
%V 36
%N 9
%@ 0885-3185
%C New York, NY
%I Wiley
%M FZJ-2021-05941
%P 2104 - 2115
%D 2021
%X Background: Corticobasal syndrome is associated with cerebral protein aggregates composed of 4-repeat (~50% of cases) or mixed 3-repeat/4-repeat tau isoforms (~25% of cases) or nontauopathies (~25% of cases).Objectives: The aim of this single-center study was to investigate the diagnostic value of the tau PET-ligand [18 F]PI-2620 in patients with corticobasal syndrome.Methods: Forty-five patients (71.5 ± 7.6 years) with corticobasal syndrome and 14 age-matched healthy controls underwent [18 F]PI-2620-PET. Beta-amyloid status was determined by cerebral β-amyloid PET and/or CSF analysis. Subcortical and cortical [18 F]PI-2620 binding was quantitatively and visually compared between β-amyloid-positive and -negative patients and controls. Regional [18 F]PI-2620 binding was correlated with clinical and demographic data.Results: Twenty-four percent (11 of 45) were β-amyloid-positive. Significantly elevated [18 F]PI-2620 distribution volume ratios were observed in both β-amyloid-positive and β-amyloid-negative patients versus controls in the dorsolateral prefrontal cortex and basal ganglia. Cortical [18 F]PI-2620 PET positivity was distinctly higher in β-amyloid-positive compared with β-amyloid-negative patients with pronounced involvement of the dorsolateral prefrontal cortex. Semiquantitative analysis of [18 F]PI-2620 PET revealed a sensitivity of 91% for β-amyloid-positive and of 65% for β-amyloid-negative cases, which is in excellent agreement with prior clinicopathological data. Regardless of β-amyloid status, hemispheric lateralization of [18 F]PI-2620 signal reflected contralateral predominance of clinical disease severity.Conclusions: Our data indicate a value of [18 F]PI-2620 for evaluating corticobasal syndrome, providing quantitatively and regionally distinct signals in β-amyloid-positive as well as β-amyloid-negative corticobasal syndrome. In corticobasal syndrome, [18 F]PI-2620 may potentially serve for a differential diagnosis and for monitoring disease progression. © 2021 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.Keywords: Alzheimer's disease; PET; corticobasal syndrome; four-repeat tauopathies; tau.
%F PUB:(DE-HGF)16
%9 Journal Article
%$ 33951244
%U <Go to ISI:>//WOS:000647195800001
%R 10.1002/mds.28624
%U https://juser.fz-juelich.de/record/904371