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@ARTICLE{Pfeil:904372,
      author       = {Pfeil, Julia and Hoenig, Merle C. and Doering, Elena and
                      van Eimeren, Thilo and Drzezga, Alexander and Bischof,
                      Gerard Nisal and Initiative, Alzheimer's Disease
                      Neuroimaging},
      title        = {{U}nique regional patterns of amyloid burden predict
                      progression to prodromal and clinical stages of
                      {A}lzheimer's disease},
      journal      = {Neurobiology of aging},
      volume       = {106},
      issn         = {0197-4580},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {FZJ-2021-05942},
      pages        = {119 - 129},
      year         = {2021},
      abstract     = {Although beta-amyloid (Aβ) positivity has shown to be
                      associated with higher risk of progression to Alzheimer's
                      disease (AD) in mild cognitive impairment (MCI), information
                      on the time to conversion to manifest dementia cannot be
                      readily deduced from this binary classification. Here, we
                      assessed if regional patterns of Aβ deposition measured
                      with 18F-florbetapir may serve as biomarker for progression
                      risk in Aβ-positive cognitively normal (CN) and MCI
                      patients, including clinical follow-up data and
                      cerebrospinal fluid (CSF) biomarkers. Voxel-wise group
                      comparisons between age and sex-matched Aβ-positive groups
                      (i.e., CN-stables [n = 38] vs. CN-to-MCI/AD progressors [n =
                      38], MCI-stables [n = 104] versus MCI-to-AD progressors [n =
                      104]) revealed higher Aβ burden in precuneus, subcortical,
                      and parietal regions in CN-to-MCI/AD progressors and
                      cingulate, temporal, and frontal regions in MCI-to-AD
                      progressors. Importantly, these regional patterns predicted
                      progression to advanced stages on the AD spectrum in the
                      short and the long-term beyond global Aβ burden and CSF
                      biomarkers. These results suggest that distinct regional
                      patterns of Aβ burden are a valuable biomarker for risk of
                      disease progression in CN and MCI.},
      cin          = {INM-2},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-2-20090406},
      pnm          = {5253 - Neuroimaging (POF4-525) / 5254 - Neuroscientific
                      Data Analytics and AI (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5253 / G:(DE-HGF)POF4-5254},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {34284259},
      UT           = {WOS:000691900600011},
      doi          = {10.1016/j.neurobiolaging.2021.06.014},
      url          = {https://juser.fz-juelich.de/record/904372},
}