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000904373 1001_ $$0P:(DE-HGF)0$$aRuppert, Marina C.$$b0$$eCorresponding author
000904373 245__ $$aThe default mode network and cognition in Parkinson's disease: A multimodal resting‐state network approach
000904373 260__ $$aNew York, NY$$bWiley-Liss$$c2021
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000904373 520__ $$aInvolvement of the default mode network (DMN) in cognitive symptoms of Parkinson's disease (PD) has been reported by resting-state functional MRI (rsfMRI) studies. However, the relation to metabolic measures obtained by [18F]-fluorodeoxyglucose positron emission tomography (FDG-PET) is largely unknown. We applied multimodal resting-state network analysis to clarify the association between intrinsic metabolic and functional connectivity abnormalities within the DMN and their significance for cognitive symptoms in PD. PD patients were classified into normal cognition (n = 36) and mild cognitive impairment (MCI; n = 12). The DMN was identified by applying an independent component analysis to FDG-PET and rsfMRI data of a matched subset (16 controls and 16 PD patients) of the total cohort. Besides metabolic activity, metabolic and functional connectivity within the DMN were compared between the patients' groups and healthy controls (n = 16). Glucose metabolism was significantly reduced in all DMN nodes in both patient groups compared to controls, with the lowest uptake in PD-MCI (p < .05). Increased metabolic and functional connectivity along fronto-parietal connections was identified in PD-MCI patients compared to controls and unimpaired patients. Functional connectivity negatively correlated with cognitive composite z-scores in patients (r = -.43, p = .005). The current study clarifies the commonalities of metabolic and hemodynamic measures of brain network activity and their individual significance for cognitive symptoms in PD, highlighting the added value of multimodal resting-state network approaches for identifying prospective biomarkers.Keywords: Parkinson's disease; [18F]-FDG-PET; default mode network; metabolic covariance; mild cognitive impairment; resting-state fMRI.
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000904373 7001_ $$0P:(DE-HGF)0$$aGreuel, Andrea$$b1
000904373 7001_ $$0P:(DE-HGF)0$$aFreigang, Julia$$b2
000904373 7001_ $$0P:(DE-HGF)0$$aTahmasian, Masoud$$b3
000904373 7001_ $$0P:(DE-HGF)0$$aMaier, Franziska$$b4
000904373 7001_ $$0P:(DE-HGF)0$$aHammes, Jochen$$b5
000904373 7001_ $$0P:(DE-HGF)0$$aEimeren, Thilo$$b6
000904373 7001_ $$0P:(DE-HGF)0$$aTimmermann, Lars$$b7
000904373 7001_ $$0P:(DE-HGF)0$$aTittgemeyer, Marc$$b8
000904373 7001_ $$0P:(DE-Juel1)177611$$aDrzezga, Alexander$$b9
000904373 7001_ $$0P:(DE-HGF)0$$aEggers, Carsten$$b10$$eCorresponding author
000904373 773__ $$0PERI:(DE-600)1492703-2$$a10.1002/hbm.25393$$gVol. 42, no. 8, p. 2623 - 2641$$n8$$p2623 - 2641$$tHuman brain mapping$$v42$$x1065-9471$$y2021
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000904373 9101_ $$0I:(DE-HGF)0$$6P:(DE-HGF)0$$a  Department of Neurology, University Hospital of Marburg, Marburg, Germany$$b0
000904373 9101_ $$0I:(DE-HGF)0$$6P:(DE-HGF)0$$a  Center for Mind, Brain, and Behavior-CMBB, Universities of Marburg and Gießen, Marburg, Germany$$b0
000904373 9101_ $$0I:(DE-HGF)0$$6P:(DE-HGF)0$$a Department of Neurology, University Hospital of Marburg, Marburg, Germany$$b1
000904373 9101_ $$0I:(DE-HGF)0$$6P:(DE-HGF)0$$a Department of Neurology, University Hospital of Marburg, Marburg, Germany$$b2
000904373 9101_ $$0I:(DE-HGF)0$$6P:(DE-HGF)0$$a Center for Mind, Brain, and Behavior-CMBB, Universities of Marburg and Gießen, Marburg, Germany$$b2
000904373 9101_ $$0I:(DE-HGF)0$$6P:(DE-HGF)0$$a Institute of Medical Science and Technology, Shahid Beheshti University, Tehran, Iran$$b3
000904373 9101_ $$0I:(DE-HGF)0$$6P:(DE-HGF)0$$a Medical Faculty, Department of Psychiatry, University Hospital Cologne, Cologne, Germany$$b4
000904373 9101_ $$0I:(DE-HGF)0$$6P:(DE-HGF)0$$a Multimodal Neuroimaging Group, Department of Nuclear Medicine, Medical Faculty and University Hospital Cologne, University Hospital Cologne, Cologne, Germany$$b5
000904373 9101_ $$0I:(DE-HGF)0$$6P:(DE-HGF)0$$a Multimodal Neuroimaging Group, Department of Nuclear Medicine, Medical Faculty and University Hospital Cologne, University Hospital Cologne, Cologne, Germany$$b6
000904373 9101_ $$0I:(DE-HGF)0$$6P:(DE-HGF)0$$a Department of Neurology, Medical Faculty and University Hospital Cologne, University Hospital Cologne, Cologne, Germany$$b6
000904373 9101_ $$0I:(DE-HGF)0$$6P:(DE-HGF)0$$a German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany$$b6
000904373 9101_ $$0I:(DE-HGF)0$$6P:(DE-HGF)0$$a  Department of Neurology, University Hospital of Marburg, Marburg, Germany$$b7
000904373 9101_ $$0I:(DE-HGF)0$$6P:(DE-HGF)0$$a  Center for Mind, Brain, and Behavior-CMBB, Universities of Marburg and Gießen, Marburg, Germany$$b7
000904373 9101_ $$0I:(DE-HGF)0$$6P:(DE-HGF)0$$a  Max Planck Institute for Metabolism Research, Cologne, Germany$$b8
000904373 9101_ $$0I:(DE-HGF)0$$6P:(DE-HGF)0$$a Cluster of Excellence in Cellular Stress and Aging Associated Disease (CECAD), Cologne, Germany$$b8
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000904373 9101_ $$0I:(DE-HGF)0$$6P:(DE-Juel1)177611$$aMultimodal Neuroimaging Group, Department of Nuclear Medicine, Medical Faculty and University Hospital Cologne, University Hospital Cologne, Cologne, Germany$$b9
000904373 9101_ $$0I:(DE-HGF)0$$6P:(DE-Juel1)177611$$a German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany$$b9
000904373 9101_ $$0I:(DE-HGF)0$$6P:(DE-HGF)0$$a Department of Neurology, University Hospital of Marburg, Marburg, Germany$$b10
000904373 9101_ $$0I:(DE-HGF)0$$6P:(DE-HGF)0$$a Center for Mind, Brain, and Behavior-CMBB, Universities of Marburg and Gießen, Marburg, Germany$$b10
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