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@ARTICLE{Adler:904377,
      author       = {Adler, Christoph and Onur, Oezguer A. and Braumann, Simon
                      and Gramespacher, Hannes and Bittner, Stefan and Falk,
                      Steffen and Fink, Gereon R. and Baldus, Stephan and Warnke,
                      Clemens},
      title        = {{A}bsolute serum neurofilament light chain levels and its
                      early kinetics predict brain injury after out-of-hospital
                      cardiac arrest},
      journal      = {Journal of neurology},
      volume       = {269},
      number       = {3},
      issn         = {0340-5354},
      address      = {Berlin},
      publisher    = {Springer},
      reportid     = {FZJ-2021-05947},
      pages        = {1530-1537},
      year         = {2022},
      abstract     = {AbstractObjectives: To test if the early kinetics of
                      neurofilament light (NFL) in blood adds to the absolute
                      values of NFL in the prediction of outcome, and to evaluate
                      if NFL can discriminate individuals with severe
                      hypoxic-ischemic brain injury (sHIBI) from those with other
                      causes of poor outcome after out-of-hospital cardiac arrest
                      (OHCA).Design and setting: Monocentric retrospective study
                      involving individuals following non-traumatic OHCA between
                      April 2014 and April 2016. NFL concentrations were
                      determined on a SiMoA HD-1 device using NF-Light Advantage
                      Kits.Participants: Of 73 patients screened, 53 had serum
                      samples available for NFL measurement at three timepoints
                      (after 3, 24, and 48 h of admission). Of these 53
                      individuals, $43.4\%$ had poor neurologic outcome at
                      discharge as assessed by Glasgow-Pittsburgh cerebral
                      performance categories, and, according to a current
                      prognostication algorithm, poor outcome due to sHIBI in
                      $20.7\%.Main$ outcome measure: Blood NFL and its early
                      kinetics for prognostication of outcome and prediction of
                      sHIBI after OHCA.Results: An absolute NFL > 508.6 pg/ml 48 h
                      after admission, or a change in NFL > 494 pg/ml compared
                      with an early baseline value predicted outcome, and
                      discriminated severe sHIBI from other causes of unfavorable
                      outcome after OHCA with high sensitivity $(100\%,$ $95\%CI$
                      $70.0-100\%)$ and specificity $(91.7\%,$ $95\%CI$
                      $62.5-100\%).Conclusions:$ Not only absolute values of NFL,
                      but also early changes in NFL predict the outcome following
                      OHCA, and may differentiate sHIBI from other causes of poor
                      outcome after OHCA with high sensitivity and specificity.
                      Our study adds to published data, overall corroborating that
                      NFL measured in blood should be implemented in
                      prognostication algorithms used in clinical
                      routine.Keywords: Brain hypoxia; Cerebral hypoxia;
                      Hypoxic–ischemic brain injury; NFL.},
      cin          = {INM-3},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406},
      pnm          = {5252 - Brain Dysfunction and Plasticity (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5252},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:34328545},
      UT           = {WOS:000679613600002},
      doi          = {10.1007/s00415-021-10722-3},
      url          = {https://juser.fz-juelich.de/record/904377},
}