%0 Journal Article
%A Stetefeld, Henning R.
%A Schaal, Alexander
%A Scheibe, Franziska
%A Nichtweiß, Julia
%A Lehmann, Felix
%A Müller, Marcus
%A Gerner, Stefan T.
%A Huttner, Hagen B.
%A Luger, Sebastian
%A Fuhrer, Hannah
%A Bösel, Julian
%A Schönenberger, Silvia
%A Dimitriadis, Konstantinos
%A Neumann, Bernhard
%A Fuchs, Kornelius
%A Fink, Gereon R.
%A Malter, Michael P.
%T Isoflurane in (Super-) Refractory Status Epilepticus: A Multicenter Evaluation
%J Neurocritical care
%V 35
%N 3
%@ 1541-6933
%C New York, NY
%I Springer
%M FZJ-2021-05955
%P 631 - 639
%D 2021
%X AbstractBackground: We aimed to determine the association between seizure termination and side effects of isoflurane forthe treatment of refractory status epilepticus (RSE) and super-refractory status epilepticus (SRSE) in neurointensivecare units (neuro-ICUs).Methods: This was a multicenter retrospective study of patients with RSE/SRSE treated with isoflurane for statusepilepticus termination admitted to the neuro-ICUs of nine German university centers during 2011–2018.Results: We identified 45 patients who received isoflurane for the treatment of RSE/SRSE. During isoflurane treat-ment, electroencephalograms showed no epileptiform discharges in 33 of 41 (80%) patients, and burst suppressionpattern was achieved in 29 of 41 patients (71%). RSE/SRSE was finally terminated after treatment with isoflurane in 23of 45 patients (51%) for the entire group and in 13 of 45 patients (29%) without additional therapy. Lengths of stay inthe hospital and in the neuro-ICU were significantly extended in cases of ongoing status epilepticus under isofluranetreatment (p = 0.01 for length of stay in the hospital, p = 0.049 for length in the neuro-ICU). During isoflurane treat-ment, side effects were reported in 40 of 45 patients (89%) and mainly included hypotension (n = 40, 89%) and/orinfection (n = 20, 44%). Whether side effects occurred did not affect the outcome at discharge. Of 22 patients withfollow-up magnetic resonance imaging, 2 patients (9%) showed progressive magnetic resonance imaging alterationsthat were considered to be potentially associated with RSE/SRSE itself or with isoflurane therapy.Conclusions: Isoflurane was associated with a good effect in stopping RSE/SRSE. Nevertheless, establishing remis-sion remained difficult. Side effects were common but without effect on the outcome at discharge.Keywords: Status epilepticus, Isoflurane, Epilepsy
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:34286464
%U <Go to ISI:>//WOS:000677824300005
%R 10.1007/s12028-021-01250-z
%U https://juser.fz-juelich.de/record/904385