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000904385 1001_ $$0P:(DE-HGF)0$$aStetefeld, Henning R.$$b0
000904385 245__ $$aIsoflurane in (Super-) Refractory Status Epilepticus: A Multicenter Evaluation
000904385 260__ $$aNew York, NY$$bSpringer$$c2021
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000904385 520__ $$aAbstractBackground: We aimed to determine the association between seizure termination and side effects of isoflurane forthe treatment of refractory status epilepticus (RSE) and super-refractory status epilepticus (SRSE) in neurointensivecare units (neuro-ICUs).Methods: This was a multicenter retrospective study of patients with RSE/SRSE treated with isoflurane for statusepilepticus termination admitted to the neuro-ICUs of nine German university centers during 2011–2018.Results: We identified 45 patients who received isoflurane for the treatment of RSE/SRSE. During isoflurane treat-ment, electroencephalograms showed no epileptiform discharges in 33 of 41 (80%) patients, and burst suppressionpattern was achieved in 29 of 41 patients (71%). RSE/SRSE was finally terminated after treatment with isoflurane in 23of 45 patients (51%) for the entire group and in 13 of 45 patients (29%) without additional therapy. Lengths of stay inthe hospital and in the neuro-ICU were significantly extended in cases of ongoing status epilepticus under isofluranetreatment (p = 0.01 for length of stay in the hospital, p = 0.049 for length in the neuro-ICU). During isoflurane treat-ment, side effects were reported in 40 of 45 patients (89%) and mainly included hypotension (n = 40, 89%) and/orinfection (n = 20, 44%). Whether side effects occurred did not affect the outcome at discharge. Of 22 patients withfollow-up magnetic resonance imaging, 2 patients (9%) showed progressive magnetic resonance imaging alterationsthat were considered to be potentially associated with RSE/SRSE itself or with isoflurane therapy.Conclusions: Isoflurane was associated with a good effect in stopping RSE/SRSE. Nevertheless, establishing remis-sion remained difficult. Side effects were common but without effect on the outcome at discharge.Keywords: Status epilepticus, Isoflurane, Epilepsy
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000904385 7001_ $$0P:(DE-HGF)0$$aSchaal, Alexander$$b1
000904385 7001_ $$0P:(DE-HGF)0$$aScheibe, Franziska$$b2
000904385 7001_ $$0P:(DE-HGF)0$$aNichtweiß, Julia$$b3
000904385 7001_ $$0P:(DE-HGF)0$$aLehmann, Felix$$b4
000904385 7001_ $$0P:(DE-HGF)0$$aMüller, Marcus$$b5
000904385 7001_ $$0P:(DE-HGF)0$$aGerner, Stefan T.$$b6
000904385 7001_ $$0P:(DE-HGF)0$$aHuttner, Hagen B.$$b7
000904385 7001_ $$0P:(DE-HGF)0$$aLuger, Sebastian$$b8
000904385 7001_ $$0P:(DE-HGF)0$$aFuhrer, Hannah$$b9
000904385 7001_ $$0P:(DE-HGF)0$$aBösel, Julian$$b10
000904385 7001_ $$0P:(DE-HGF)0$$aSchönenberger, Silvia$$b11
000904385 7001_ $$0P:(DE-HGF)0$$aDimitriadis, Konstantinos$$b12
000904385 7001_ $$0P:(DE-HGF)0$$aNeumann, Bernhard$$b13
000904385 7001_ $$0P:(DE-HGF)0$$aFuchs, Kornelius$$b14
000904385 7001_ $$0P:(DE-Juel1)131720$$aFink, Gereon R.$$b15$$ufzj
000904385 7001_ $$00000-0003-2535-4553$$aMalter, Michael P.$$b16$$eCorresponding author
000904385 773__ $$0PERI:(DE-600)2176033-0$$a10.1007/s12028-021-01250-z$$gVol. 35, no. 3, p. 631 - 639$$n3$$p631 - 639$$tNeurocritical care$$v35$$x1541-6933$$y2021
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