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@ARTICLE{Stetefeld:904385,
      author       = {Stetefeld, Henning R. and Schaal, Alexander and Scheibe,
                      Franziska and Nichtweiß, Julia and Lehmann, Felix and
                      Müller, Marcus and Gerner, Stefan T. and Huttner, Hagen B.
                      and Luger, Sebastian and Fuhrer, Hannah and Bösel, Julian
                      and Schönenberger, Silvia and Dimitriadis, Konstantinos and
                      Neumann, Bernhard and Fuchs, Kornelius and Fink, Gereon R.
                      and Malter, Michael P.},
      title        = {{I}soflurane in ({S}uper-) {R}efractory {S}tatus
                      {E}pilepticus: {A} {M}ulticenter {E}valuation},
      journal      = {Neurocritical care},
      volume       = {35},
      number       = {3},
      issn         = {1541-6933},
      address      = {New York, NY},
      publisher    = {Springer},
      reportid     = {FZJ-2021-05955},
      pages        = {631 - 639},
      year         = {2021},
      abstract     = {AbstractBackground: We aimed to determine the association
                      between seizure termination and side effects of isoflurane
                      forthe treatment of refractory status epilepticus (RSE) and
                      super-refractory status epilepticus (SRSE) in
                      neurointensivecare units (neuro-ICUs).Methods: This was a
                      multicenter retrospective study of patients with RSE/SRSE
                      treated with isoflurane for statusepilepticus termination
                      admitted to the neuro-ICUs of nine German university centers
                      during 2011–2018.Results: We identified 45 patients who
                      received isoflurane for the treatment of RSE/SRSE. During
                      isoflurane treat-ment, electroencephalograms showed no
                      epileptiform discharges in 33 of 41 $(80\%)$ patients, and
                      burst suppressionpattern was achieved in 29 of 41 patients
                      $(71\%).$ RSE/SRSE was finally terminated after treatment
                      with isoflurane in 23of 45 patients $(51\%)$ for the entire
                      group and in 13 of 45 patients $(29\%)$ without additional
                      therapy. Lengths of stay inthe hospital and in the neuro-ICU
                      were significantly extended in cases of ongoing status
                      epilepticus under isofluranetreatment (p = 0.01 for length
                      of stay in the hospital, p = 0.049 for length in the
                      neuro-ICU). During isoflurane treat-ment, side effects were
                      reported in 40 of 45 patients $(89\%)$ and mainly included
                      hypotension (n = 40, $89\%)$ and/orinfection (n = 20,
                      $44\%).$ Whether side effects occurred did not affect the
                      outcome at discharge. Of 22 patients withfollow-up magnetic
                      resonance imaging, 2 patients $(9\%)$ showed progressive
                      magnetic resonance imaging alterationsthat were considered
                      to be potentially associated with RSE/SRSE itself or with
                      isoflurane therapy.Conclusions: Isoflurane was associated
                      with a good effect in stopping RSE/SRSE. Nevertheless,
                      establishing remis-sion remained difficult. Side effects
                      were common but without effect on the outcome at
                      discharge.Keywords: Status epilepticus, Isoflurane,
                      Epilepsy},
      cin          = {INM-3},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406},
      pnm          = {5252 - Brain Dysfunction and Plasticity (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5252},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:34286464},
      UT           = {WOS:000677824300005},
      doi          = {10.1007/s12028-021-01250-z},
      url          = {https://juser.fz-juelich.de/record/904385},
}