000904404 001__ 904404
000904404 005__ 20220224125209.0
000904404 0247_ $$2doi$$a10.1007/s10548-021-00876-8
000904404 0247_ $$2ISSN$$a0896-0267
000904404 0247_ $$2ISSN$$a1573-6792
000904404 0247_ $$2Handle$$a2128/30521
000904404 0247_ $$2pmid$$a34642836
000904404 0247_ $$2WOS$$aWOS:000706573000001
000904404 037__ $$aFZJ-2021-05974
000904404 082__ $$a610
000904404 1001_ $$00000-0002-3283-2691$$aForsyth, Anna E. M.$$b0$$eCorresponding author
000904404 245__ $$aEffects of Ketamine and Midazolam on Simultaneous EEG/fMRI Data During Working Memory Processes
000904404 260__ $$aDordrecht [u.a.]$$bSpringer Science + Business Media B.V$$c2021
000904404 3367_ $$2DRIVER$$aarticle
000904404 3367_ $$2DataCite$$aOutput Types/Journal article
000904404 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1643034183_6536
000904404 3367_ $$2BibTeX$$aARTICLE
000904404 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000904404 3367_ $$00$$2EndNote$$aJournal Article
000904404 520__ $$aReliable measures of cognitive brain activity from functional neuroimaging techniques may provide early indications of efficacy in clinical trials. Functional magnetic resonance imaging and electroencephalography provide complementary spatiotemporal information and simultaneous recording of these two modalities can remove inter-session drug response and environment variability. We sought to assess the effects of ketamine and midazolam on simultaneous electrophysiological and hemodynamic recordings during working memory (WM) processes. Thirty participants were included in a placebo-controlled, three-way crossover design with ketamine and midazolam. Compared to placebo, ketamine administration attenuated theta power increases and alpha power decreases and midazolam attenuated low beta band decreases to increasing WM load. Additionally, ketamine caused larger blood-oxygen-dependent (BOLD) signal increases in the supplementary motor area and angular gyrus, and weaker deactivations of the default mode network (DMN), whereas no difference was found between midazolam and placebo. Ketamine administration caused positive temporal correlations between frontal-midline theta (fm-theta) power and the BOLD signal to disappear and attenuated negative correlations. However, the relationship between fm-theta and the BOLD signal from DMN areas was maintained in some participants during ketamine administration, as increasing theta strength was associated with stronger BOLD signal reductions in these areas. The presence of, and ability to manipulate, both positive and negative associations between the BOLD signal and fm-theta suggest the presence of multiple fm-theta components involved in WM processes, with ketamine administration disrupting one or more of these theta-linked WM strategies.
000904404 536__ $$0G:(DE-HGF)POF4-5251$$a5251 - Multilevel Brain Organization and Variability (POF4-525)$$cPOF4-525$$fPOF IV$$x0
000904404 588__ $$aDataset connected to CrossRef, Journals: juser.fz-juelich.de
000904404 7001_ $$00000-0002-4811-5187$$aMcMillan, Rebecca$$b1
000904404 7001_ $$0P:(DE-Juel1)177727$$aDukart, Juergen$$b2
000904404 7001_ $$00000-0002-7875-2988$$aHipp, Jörg F.$$b3
000904404 7001_ $$00000-0001-7042-3920$$aMuthukumaraswamy, Suresh D.$$b4
000904404 773__ $$0PERI:(DE-600)2015003-9$$a10.1007/s10548-021-00876-8$$gVol. 34, no. 6, p. 863 - 880$$n6$$p863 - 880$$tBrain topography$$v34$$x0896-0267$$y2021
000904404 8564_ $$uhttps://juser.fz-juelich.de/record/904404/files/Forsyth2021_Article_EffectsOfKetamineAndMidazolamO.pdf$$yRestricted
000904404 8564_ $$uhttps://juser.fz-juelich.de/record/904404/files/Forsyth_2021%20Nback%20Manuscript%20For%20Submission.pdf$$yPublished on 2021-10-13. Available in OpenAccess from 2022-10-13.
000904404 909CO $$ooai:juser.fz-juelich.de:904404$$pdnbdelivery$$pdriver$$pVDB$$popen_access$$popenaire
000904404 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)177727$$aForschungszentrum Jülich$$b2$$kFZJ
000904404 9131_ $$0G:(DE-HGF)POF4-525$$1G:(DE-HGF)POF4-520$$2G:(DE-HGF)POF4-500$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$9G:(DE-HGF)POF4-5251$$aDE-HGF$$bKey Technologies$$lNatural, Artificial and Cognitive Information Processing$$vDecoding Brain Organization and Dysfunction$$x0
000904404 9141_ $$y2021
000904404 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS$$d2021-01-31
000904404 915__ $$0StatID:(DE-HGF)0160$$2StatID$$aDBCoverage$$bEssential Science Indicators$$d2021-01-31
000904404 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews$$d2021-01-31
000904404 915__ $$0StatID:(DE-HGF)1190$$2StatID$$aDBCoverage$$bBiological Abstracts$$d2021-01-31
000904404 915__ $$0StatID:(DE-HGF)0530$$2StatID$$aEmbargoed OpenAccess
000904404 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bBRAIN TOPOGR : 2019$$d2021-01-31
000904404 915__ $$0StatID:(DE-HGF)1030$$2StatID$$aDBCoverage$$bCurrent Contents - Life Sciences$$d2021-01-31
000904404 915__ $$0StatID:(DE-HGF)3002$$2StatID$$aDEAL Springer$$d2021-01-31$$wger
000904404 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection$$d2021-01-31
000904404 915__ $$0StatID:(DE-HGF)9900$$2StatID$$aIF < 5$$d2021-01-31
000904404 915__ $$0StatID:(DE-HGF)0113$$2StatID$$aWoS$$bScience Citation Index Expanded$$d2021-01-31
000904404 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline$$d2021-01-31
000904404 915__ $$0StatID:(DE-HGF)0420$$2StatID$$aNationallizenz$$d2021-01-31$$wger
000904404 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List$$d2021-01-31
000904404 920__ $$lyes
000904404 9201_ $$0I:(DE-Juel1)INM-7-20090406$$kINM-7$$lGehirn & Verhalten$$x0
000904404 980__ $$ajournal
000904404 980__ $$aVDB
000904404 980__ $$aUNRESTRICTED
000904404 980__ $$aI:(DE-Juel1)INM-7-20090406
000904404 9801_ $$aFullTexts