% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Park:904412,
      author       = {Park, Shinwon and Haak, Koen V. and Cho, Han Byul and Valk,
                      Sofie L. and Bethlehem, Richard A. I. and Milham, Michael P.
                      and Bernhardt, Boris C. and Di Martino, Adriana and Hong,
                      Seok-Jun},
      title        = {{A}typical {I}ntegration of {S}ensory-to-{T}ransmodal
                      {F}unctional {S}ystems {M}ediates {S}ymptom {S}everity in
                      {A}utism},
      journal      = {Frontiers in psychiatry},
      volume       = {12},
      issn         = {1664-0640},
      address      = {Lausanne},
      publisher    = {Frontiers Research Foundation},
      reportid     = {FZJ-2021-05982},
      pages        = {699813},
      year         = {2021},
      abstract     = {A notable characteristic of autism spectrum disorder (ASD)
                      is co-occurring deficits in low-level sensory processing and
                      high-order social interaction. While there is evidence
                      indicating detrimental cascading effects of sensory
                      anomalies on the high-order cognitive functions in ASD, the
                      exact pathological mechanism underlying their atypical
                      functional interaction across the cortical hierarchy has not
                      been systematically investigated. To address this gap, here
                      we assessed the functional organisation of sensory and motor
                      areas in ASD, and their relationship with subcortical and
                      high-order trandmodal systems. In a resting-state fMRI data
                      of 107 ASD and 113 neurotypical individuals, we applied
                      advanced connectopic mapping to probe functional
                      organization of primary sensory/motor areas, together with
                      targeted seed-based intrinsic functional connectivity (iFC)
                      analyses. In ASD, the connectopic mapping revealed
                      topological anomalies (i.e., excessively more segregated
                      iFC) in the motor and visual areas, the former of which
                      patterns showed association with the symptom severity of
                      restricted and repetitive behaviors. Moreover, the
                      seed-based analysis found diverging patterns of ASD-related
                      connectopathies: decreased iFCs within the sensory/motor
                      areas but increased iFCs between sensory and subcortical
                      structures. While decreased iFCs were also found within the
                      higher-order functional systems, the overall proportion of
                      this anomaly tends to increase along the level of cortical
                      hierarchy, suggesting more dysconnectivity in the
                      higher-order functional networks. Finally, we demonstrated
                      that the association between low-level sensory/motor iFCs
                      and clinical symptoms in ASD was mediated by the high-order
                      transmodal systems, suggesting pathogenic functional
                      interactions along the cortical hierarchy. Findings were
                      largely replicated in the independent dataset. These results
                      highlight that atypical integration of sensory-to-high-order
                      systems contributes to the complex ASD symptomatology.},
      cin          = {INM-7},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-7-20090406},
      pnm          = {5251 - Multilevel Brain Organization and Variability
                      (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5251},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:34489757},
      UT           = {WOS:000696038500001},
      doi          = {10.3389/fpsyt.2021.699813},
      url          = {https://juser.fz-juelich.de/record/904412},
}