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@ARTICLE{Puhlmann:904413,
      author       = {Puhlmann, L. M. C. and Linz, R. and Valk, S. L. and
                      Vrticka, P. and Vos de Wael, R. and Bernasconi, A. and
                      Bernasconi, N. and Caldairou, B. and Papassotiriou, I. and
                      Chrousos, G. P. and Bernhardt, B. C. and Singer, T. and
                      Engert, V.},
      title        = {{A}ssociation between hippocampal structure and serum
                      {B}rain-{D}erived {N}eurotrophic {F}actor ({BDNF}) in
                      healthy adults: {A} registered report},
      journal      = {NeuroImage},
      volume       = {236},
      issn         = {1053-8119},
      address      = {Orlando, Fla.},
      publisher    = {Academic Press},
      reportid     = {FZJ-2021-05983},
      pages        = {118011 -},
      year         = {2021},
      abstract     = {The hippocampus is a highly plastic brain structure
                      supporting functions central to human cognition.
                      Morphological changes in the hippocampus have been
                      implicated in development, aging, as well as in a broad
                      range of neurological and psychiatric disorders. A growing
                      body of research suggests that hippocampal plasticity is
                      closely linked to the actions of brain-derived neurotrophic
                      factor (BDNF). However, evidence on the relationship between
                      hippocampal volume (HCV) and peripheral BDNF levels is
                      scarce and limited to elderly and patient populations.
                      Further, despite evidence that BDNF expression differs
                      throughout the hippocampus and is implicated in adult
                      neurogenesis specifically in the dentate gyrus, no study has
                      so far related peripheral BDNF levels to the volumes of
                      individual hippocampal subfields. Besides its clinical
                      implications, BDNF-facilitated hippocampal plasticity plays
                      an important role in regulating cognitive and affective
                      processes. In the current registered report, we investigated
                      how serum BDNF (sBDNF) levels relate to volumes of the
                      hippocampal formation and its subfields in a large sample of
                      healthy adults (N = 279, 160 f) with a broad age range
                      (20–55 years, mean 40.5) recruited in the context of the
                      ReSource Project. We related HCV to basal sBDNF and, in a
                      subsample (n = 103, 57 f), to acute stress-reactive change
                      in sBDNF. We further tested the role of age as a moderator
                      of both associations. Contrary to our hypotheses, neither
                      basal sBDNF levels nor stress-reactive sBDNF change were
                      associated with total HCV or volume of the dentate
                      gyrus/cornu ammonis 4 (DG/CA4) subfield. We also found no
                      evidence for a moderating effect of age on any of these
                      associations. Our null results provide a first point of
                      reference on the relationship between sBDNF and HCV in
                      healthy mid-age, in contrast to patient or aging
                      populations. We suggest that sBDNF levels have limited
                      predictive value for morphological differences of the
                      hippocampal structure when notable challenge to its neuronal
                      integrity or to neurotrophic capacity is absent.},
      cin          = {INM-7},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-7-20090406},
      pnm          = {5251 - Multilevel Brain Organization and Variability
                      (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5251},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:33852941},
      UT           = {WOS:000670278100001},
      doi          = {10.1016/j.neuroimage.2021.118011},
      url          = {https://juser.fz-juelich.de/record/904413},
}