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000904416 1001_ $$0P:(DE-HGF)0$$aClemens, Benjamin$$b0$$eCorresponding author
000904416 245__ $$aReplication of Previous Findings? Comparing Gray Matter Volumes in Transgender Individuals with Gender Incongruence and Cisgender Individuals
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000904416 520__ $$aThe brain structural changes related to gender incongruence (GI) are still poorly understood. Previous studies comparing gray matter volumes (GMV) between cisgender and transgender individuals with GI revealed conflicting results. Leveraging a comprehensive sample of transmen (n = 33), transwomen (n = 33), cismen (n = 24), and ciswomen (n = 25), we employ a region-of-interest (ROI) approach to examine the most frequently reported brain regions showing GMV differences between trans- and cisgender individuals. The primary aim is to replicate previous findings and identify anatomical regions which differ between transgender individuals with GI and cisgender individuals. On the basis of a comprehensive literature search, we selected a set of ROIs (thalamus, putamen, cerebellum, angular gyrus, precentral gyrus) for which differences between cis- and transgender groups have been previously observed. The putamen was the only region showing significant GMV differences between cis- and transgender, across previous studies and the present study. We observed increased GMV in the putamen for transwomen compared to both transmen and ciswomen and for all transgender participants compared to all cisgender participants. Such a pattern of neuroanatomical differences corroborates the large majority of previous studies. This potential replication of previous findings and the known involvement of the putamen in cognitive processes related to body representations and the creation of the own body image indicate the relevance of this region for GI and its potential as a structural biomarker for GI
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000904416 7001_ $$0P:(DE-Juel1)166584$$aVotinov, Mikhail$$b1
000904416 7001_ $$00000-0002-0074-5251$$aPuiu, Andrei Alexandru$$b2
000904416 7001_ $$0P:(DE-HGF)0$$aSchüppen, Andre$$b3
000904416 7001_ $$0P:(DE-Juel1)179395$$aHüpen, Philippa$$b4
000904416 7001_ $$0P:(DE-HGF)0$$aNeulen, Josef$$b5
000904416 7001_ $$0P:(DE-HGF)0$$aDerntl, Birgit$$b6
000904416 7001_ $$0P:(DE-Juel1)172840$$aHabel, Ute$$b7$$ufzj
000904416 773__ $$0PERI:(DE-600)2662592-1$$a10.3390/jcm10071454$$gVol. 10, no. 7, p. 1454 -$$n7$$p1454 -$$tJournal of Clinical Medicine$$v10$$x2077-0383$$y2021
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