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@ARTICLE{Clemens:904416,
      author       = {Clemens, Benjamin and Votinov, Mikhail and Puiu, Andrei
                      Alexandru and Schüppen, Andre and Hüpen, Philippa and
                      Neulen, Josef and Derntl, Birgit and Habel, Ute},
      title        = {{R}eplication of {P}revious {F}indings? {C}omparing {G}ray
                      {M}atter {V}olumes in {T}ransgender {I}ndividuals with
                      {G}ender {I}ncongruence and {C}isgender {I}ndividuals},
      journal      = {Journal of Clinical Medicine},
      volume       = {10},
      number       = {7},
      issn         = {2077-0383},
      address      = {Basel},
      publisher    = {MDPI},
      reportid     = {FZJ-2021-05986},
      pages        = {1454 -},
      year         = {2021},
      abstract     = {The brain structural changes related to gender incongruence
                      (GI) are still poorly understood. Previous studies comparing
                      gray matter volumes (GMV) between cisgender and transgender
                      individuals with GI revealed conflicting results. Leveraging
                      a comprehensive sample of transmen (n = 33), transwomen (n =
                      33), cismen (n = 24), and ciswomen (n = 25), we employ a
                      region-of-interest (ROI) approach to examine the most
                      frequently reported brain regions showing GMV differences
                      between trans- and cisgender individuals. The primary aim is
                      to replicate previous findings and identify anatomical
                      regions which differ between transgender individuals with GI
                      and cisgender individuals. On the basis of a comprehensive
                      literature search, we selected a set of ROIs (thalamus,
                      putamen, cerebellum, angular gyrus, precentral gyrus) for
                      which differences between cis- and transgender groups have
                      been previously observed. The putamen was the only region
                      showing significant GMV differences between cis- and
                      transgender, across previous studies and the present study.
                      We observed increased GMV in the putamen for transwomen
                      compared to both transmen and ciswomen and for all
                      transgender participants compared to all cisgender
                      participants. Such a pattern of neuroanatomical differences
                      corroborates the large majority of previous studies. This
                      potential replication of previous findings and the known
                      involvement of the putamen in cognitive processes related to
                      body representations and the creation of the own body image
                      indicate the relevance of this region for GI and its
                      potential as a structural biomarker for GI},
      cin          = {INM-10},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-10-20170113},
      pnm          = {5252 - Brain Dysfunction and Plasticity (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5252},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:33916288},
      UT           = {WOS:000638651300001},
      doi          = {10.3390/jcm10071454},
      url          = {https://juser.fz-juelich.de/record/904416},
}