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@ARTICLE{Kuhn:904421,
      author       = {Kuhn, Leandra and Noack, Hannes and Skoluda, Nadine and
                      Wagels, Lisa and Röhr, Ann-Kristin and Schulte, Christina
                      and Eisenkolb, Sana and Nieratschker, Vanessa and Derntl,
                      Birgit and Habel, Ute},
      title        = {{T}he association of the 5-{HTTLPR} polymorphism and the
                      response to different stressors in healthy males},
      journal      = {Journal of neural transmission},
      volume       = {128},
      number       = {9},
      issn         = {0300-9564},
      address      = {Wien [u.a.]},
      publisher    = {Springer},
      reportid     = {FZJ-2021-05991},
      pages        = {1347 - 1359},
      year         = {2021},
      abstract     = {The experience of stress is related to individual wellbeing
                      and vulnerability to psychopathology. Therefore,
                      understanding the determinants of individual differences in
                      stress reactivity is of great concern from a clinical
                      perspective. The functional promotor polymorphism of the
                      serotonin transporter gene (5-HTTLPR/rs25531) is such a
                      factor, which has been linked to the acute stress response
                      as well as the adverse effect of life stressors. In the
                      present study, we compared the impact of two different
                      stress induction protocols (Maastricht Acute Stress Test and
                      ScanSTRESS) and the respective control conditions on
                      affective ratings, salivary cortisol levels and cognitive
                      performance. To this end, 156 healthy young males were
                      tested and genotyped for the 5-HTTLPR/rs25531 polymorphism.
                      While combined physiological and psychological stress in the
                      MAST led to a greater cortisol increase compared to control
                      conditions as well as the psychosocial ScanSTRESS,
                      subjective stress ratings were highest in the ScanSTRESS
                      condition. Stress induction in general affected working
                      memory capacity but not response inhibition. Subjective
                      stress was also influenced by 5-HTTLPR/rs25531 genotype with
                      the high expression group showing lower stress ratings than
                      lower expression groups. In line with previous research, we
                      identified the low expression variant of the serotonin
                      transporter gene as a risk factor for increased stress
                      reactivity. While some dimensions of the human stress
                      response may be stressor specific, cognitive outcomes such
                      as working memory performance are influenced by stress in
                      general. Different pathways of stress processing and
                      possible underlying mechanisms are discussed.},
      cin          = {INM-10},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-10-20170113},
      pnm          = {5252 - Brain Dysfunction and Plasticity (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5252},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {34374855},
      UT           = {WOS:000683640800001},
      doi          = {10.1007/s00702-021-02390-4},
      url          = {https://juser.fz-juelich.de/record/904421},
}