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@ARTICLE{Kallscheuer:904481,
      author       = {Kallscheuer, Nicolai and Jogler, Christian},
      title        = {{T}he bacterial phylum {P}lanctomycetes as novel source for
                      bioactive small molecules},
      journal      = {Biotechnology advances},
      volume       = {53},
      issn         = {0734-9750},
      address      = {Amsterdam},
      publisher    = {Elsevier Science Publ.},
      reportid     = {FZJ-2021-06051},
      pages        = {107818 -},
      year         = {2021},
      abstract     = {Extensive knowledge and methodological expertise on the
                      bacterial cell biology have been accumulated over the last
                      decades and bacterial cells have now become an integral part
                      of several (bio-)technological processes. While it appears
                      reasonable to focus on a relatively small number of
                      fast-growing and genetically easily manipulable model
                      bacteria as biotechnological workhorses, the for the most
                      part untapped diversity of bacteria needs to be explored
                      when it comes to bioprospecting for natural product
                      discovery. Members of the underexplored and evolutionarily
                      deep-branching phylum Planctomycetes have only recently
                      gained increased attention with respect to the production of
                      small molecules with biomedical activities, e.g. as a
                      natural source of novel antibiotics. Next-generation
                      sequencing and metagenomics can provide access to the
                      genomes of uncultivated bacteria from sparsely studied
                      phyla, this, however, should be regarded as an addition
                      rather than a substitute for classical strain isolation
                      approaches. Ten years ago, a large sampling campaign was
                      initiated to isolate planctomycetes from their varied
                      natural habitats and protocols were developed to address
                      complications during cultivation of representative species
                      in the laboratory. The characterisation of approximately 90
                      novel strains by several research groups in the recent years
                      opened a detailed in silico look into the coding potential
                      of individual members of this phylum. Here, we review the
                      current state of planctomycetal research, focusing on
                      diversity, small molecule production and potential future
                      applications. Although the field developed promising, the
                      time frame of 10 years illustrates that the study of
                      additional promising bacterial phyla as sources for novel
                      small molecules needs to start rather today than tomorrow.},
      cin          = {IBG-1},
      ddc          = {570},
      cid          = {I:(DE-Juel1)IBG-1-20101118},
      pnm          = {2172 - Utilization of renewable carbon and energy sources
                      and engineering of ecosystem functions (POF4-217)},
      pid          = {G:(DE-HGF)POF4-2172},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:34537319},
      UT           = {WOS:000703667400003},
      doi          = {10.1016/j.biotechadv.2021.107818},
      url          = {https://juser.fz-juelich.de/record/904481},
}