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@ARTICLE{Nguyen:904486,
      author       = {Nguyen, Bach-Ngan and Tieves, Florian and Rohr, Thomas and
                      Wobst, Hilke and Schöpf, Felix S. and Solano, Jóse D.
                      Montoya and Schneider, Julia and Stock, Janpeter and Uhde,
                      Andreas and Kalthoff, Thomas and Jaeger, Karl Erich and
                      Schmitt, Lutz and Schwarz, Christian},
      title        = {{N}umaswitch: an efficient high-titer expression platform
                      to produce peptides and small proteins},
      journal      = {AMB express},
      volume       = {11},
      number       = {1},
      issn         = {2191-0855},
      address      = {Heidelberg},
      publisher    = {Springer},
      reportid     = {FZJ-2021-06056},
      pages        = {48},
      year         = {2021},
      abstract     = {The production of peptides as active pharmaceutical
                      ingredients (APIs) by recombinant technologies is of
                      emerging interest. A reliable production platform, however,
                      is still missing due the inherent characteristics of
                      peptides such as proteolytic sensitivity, aggregation and
                      cytotoxicity. We have developed a new technology named
                      Numaswitch solving present limitations. Numaswitch was
                      successfully employed for the production of diverse peptides
                      and small proteins varying in length, physicochemical and
                      functional characteristics, including Teriparatide,
                      Linaclotide, human β-amyloid and Serum amyloid A3.
                      Additionally, the potential of Numaswitch for a
                      cost-efficient commercial production is demonstrated
                      yielding > 2 g Teriparatide per liter fermentation broth
                      in a quality meeting API standard.},
      cin          = {IBG-1 / IMET},
      ddc          = {570},
      cid          = {I:(DE-Juel1)IBG-1-20101118 / I:(DE-Juel1)IMET-20090612},
      pnm          = {2172 - Utilization of renewable carbon and energy sources
                      and engineering of ecosystem functions (POF4-217)},
      pid          = {G:(DE-HGF)POF4-2172},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:33765268},
      UT           = {WOS:000632906300001},
      doi          = {10.1186/s13568-021-01204-w},
      url          = {https://juser.fz-juelich.de/record/904486},
}