%0 Journal Article
%A Winand, Lea
%A Schneider, Pascal
%A Kruth, Sebastian
%A Greven, Nico-Joel
%A Hiller, Wolf
%A Kaiser, Marcel
%A Pietruszka, Jörg
%A Nett, Markus
%T Mutasynthesis of Physostigmines in Myxococcus xanthus
%J Organic letters
%V 23
%N 16
%@ 1523-7052
%C Washington, DC
%I ACS
%M FZJ-2021-06060
%P 6563 - 6567
%D 2021
%X The alkaloid physostigmine is an approved anticholinergic drug and an important lead structure for the development of novel therapeutics. Using a complementary approach that merged chemical synthesis with pathway refactoring, we produced a series of physostigmine analogues with altered specificity and toxicity profiles in the heterologous host Myxococcus xanthus. The compounds that were generated by applying a simple feeding strategy include the promising drug candidate phenserine, which was previously accessible only by total synthesis.
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:34355569
%U <Go to ISI:>//WOS:000687930500073
%R 10.1021/acs.orglett.1c02374
%U https://juser.fz-juelich.de/record/904490