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000904490 245__ $$aMutasynthesis of Physostigmines in Myxococcus xanthus
000904490 260__ $$aWashington, DC$$bACS$$c2021
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000904490 520__ $$aThe alkaloid physostigmine is an approved anticholinergic drug and an important lead structure for the development of novel therapeutics. Using a complementary approach that merged chemical synthesis with pathway refactoring, we produced a series of physostigmine analogues with altered specificity and toxicity profiles in the heterologous host Myxococcus xanthus. The compounds that were generated by applying a simple feeding strategy include the promising drug candidate phenserine, which was previously accessible only by total synthesis.
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000904490 7001_ $$0P:(DE-Juel1)176354$$aSchneider, Pascal$$b1$$ufzj
000904490 7001_ $$0P:(DE-HGF)0$$aKruth, Sebastian$$b2
000904490 7001_ $$0P:(DE-HGF)0$$aGreven, Nico-Joel$$b3
000904490 7001_ $$0P:(DE-HGF)0$$aHiller, Wolf$$b4
000904490 7001_ $$0P:(DE-HGF)0$$aKaiser, Marcel$$b5
000904490 7001_ $$0P:(DE-Juel1)128906$$aPietruszka, Jörg$$b6$$ufzj
000904490 7001_ $$0P:(DE-HGF)0$$aNett, Markus$$b7$$eCorresponding author
000904490 773__ $$0PERI:(DE-600)1501522-1$$a10.1021/acs.orglett.1c02374$$gVol. 23, no. 16, p. 6563 - 6567$$n16$$p6563 - 6567$$tOrganic letters$$v23$$x1523-7052$$y2021
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