TY  - JOUR
AU  - Winand, Lea
AU  - Schneider, Pascal
AU  - Kruth, Sebastian
AU  - Greven, Nico-Joel
AU  - Hiller, Wolf
AU  - Kaiser, Marcel
AU  - Pietruszka, Jörg
AU  - Nett, Markus
TI  - Mutasynthesis of Physostigmines in Myxococcus xanthus
JO  - Organic letters
VL  - 23
IS  - 16
SN  - 1523-7052
CY  - Washington, DC
PB  - ACS
M1  - FZJ-2021-06060
SP  - 6563 - 6567
PY  - 2021
AB  - The alkaloid physostigmine is an approved anticholinergic drug and an important lead structure for the development of novel therapeutics. Using a complementary approach that merged chemical synthesis with pathway refactoring, we produced a series of physostigmine analogues with altered specificity and toxicity profiles in the heterologous host Myxococcus xanthus. The compounds that were generated by applying a simple feeding strategy include the promising drug candidate phenserine, which was previously accessible only by total synthesis.
LB  - PUB:(DE-HGF)16
C6  - pmid:34355569
UR  - <Go to ISI:>//WOS:000687930500073
DO  - DOI:10.1021/acs.orglett.1c02374
UR  - https://juser.fz-juelich.de/record/904490
ER  -