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@ARTICLE{Winand:904490,
      author       = {Winand, Lea and Schneider, Pascal and Kruth, Sebastian and
                      Greven, Nico-Joel and Hiller, Wolf and Kaiser, Marcel and
                      Pietruszka, Jörg and Nett, Markus},
      title        = {{M}utasynthesis of {P}hysostigmines in {M}yxococcus
                      xanthus},
      journal      = {Organic letters},
      volume       = {23},
      number       = {16},
      issn         = {1523-7052},
      address      = {Washington, DC},
      publisher    = {ACS},
      reportid     = {FZJ-2021-06060},
      pages        = {6563 - 6567},
      year         = {2021},
      abstract     = {The alkaloid physostigmine is an approved anticholinergic
                      drug and an important lead structure for the development of
                      novel therapeutics. Using a complementary approach that
                      merged chemical synthesis with pathway refactoring, we
                      produced a series of physostigmine analogues with altered
                      specificity and toxicity profiles in the heterologous host
                      Myxococcus xanthus. The compounds that were generated by
                      applying a simple feeding strategy include the promising
                      drug candidate phenserine, which was previously accessible
                      only by total synthesis.},
      cin          = {IBG-1 / IBOC},
      ddc          = {540},
      cid          = {I:(DE-Juel1)IBG-1-20101118 / I:(DE-Juel1)IBOC-20090406},
      pnm          = {2171 - Biological and environmental resources for
                      sustainable use (POF4-217)},
      pid          = {G:(DE-HGF)POF4-2171},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:34355569},
      UT           = {WOS:000687930500073},
      doi          = {10.1021/acs.orglett.1c02374},
      url          = {https://juser.fz-juelich.de/record/904490},
}