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| 001 | 904490 | ||
| 005 | 20220131120428.0 | ||
| 024 | 7 | _ | |a 10.1021/acs.orglett.1c02374 |2 doi |
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| 100 | 1 | _ | |a Winand, Lea |0 P:(DE-HGF)0 |b 0 |
| 245 | _ | _ | |a Mutasynthesis of Physostigmines in Myxococcus xanthus |
| 260 | _ | _ | |a Washington, DC |c 2021 |b ACS |
| 336 | 7 | _ | |a article |2 DRIVER |
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| 520 | _ | _ | |a The alkaloid physostigmine is an approved anticholinergic drug and an important lead structure for the development of novel therapeutics. Using a complementary approach that merged chemical synthesis with pathway refactoring, we produced a series of physostigmine analogues with altered specificity and toxicity profiles in the heterologous host Myxococcus xanthus. The compounds that were generated by applying a simple feeding strategy include the promising drug candidate phenserine, which was previously accessible only by total synthesis. |
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| 700 | 1 | _ | |a Schneider, Pascal |0 P:(DE-Juel1)176354 |b 1 |u fzj |
| 700 | 1 | _ | |a Kruth, Sebastian |0 P:(DE-HGF)0 |b 2 |
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| 700 | 1 | _ | |a Pietruszka, Jörg |0 P:(DE-Juel1)128906 |b 6 |u fzj |
| 700 | 1 | _ | |a Nett, Markus |0 P:(DE-HGF)0 |b 7 |e Corresponding author |
| 773 | _ | _ | |a 10.1021/acs.orglett.1c02374 |g Vol. 23, no. 16, p. 6563 - 6567 |0 PERI:(DE-600)1501522-1 |n 16 |p 6563 - 6567 |t Organic letters |v 23 |y 2021 |x 1523-7052 |
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