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@ARTICLE{Beleggia:904492,
      author       = {Beleggia, Romina and Omranian, Nooshin and Holtz, Yan and
                      Gioia, Tania and Fiorani, Fabio and Nigro, Franca M. and
                      Pecchioni, Nicola and De Vita, Pasquale and Schurr, Ulrich
                      and David, Jacques L. and Nikoloski, Zoran and Papa,
                      Roberto},
      title        = {{C}omparative {A}nalysis {B}ased on {T}ranscriptomics and
                      {M}etabolomics {D}ata {R}eveal {D}ifferences between {E}mmer
                      and {D}urum {W}heat in {R}esponse to {N}itrogen
                      {S}tarvation},
      journal      = {International journal of molecular sciences},
      volume       = {22},
      number       = {9},
      issn         = {1422-0067},
      address      = {Basel},
      publisher    = {Molecular Diversity Preservation International},
      reportid     = {FZJ-2021-06062},
      pages        = {4790 -},
      year         = {2021},
      abstract     = {Mounting evidence indicates the key role of nitrogen (N) on
                      diverse processes in plant, including development and
                      defense. Using a combined transcriptomics and metabolomics
                      approach, we studied the response of seedlings to N
                      starvation of two different tetraploid wheat genotypes from
                      the two main domesticated subspecies: emmer and durum wheat.
                      We found that durum wheat exhibits broader and stronger
                      response in comparison to emmer as seen from the expression
                      pattern of both genes and metabolites and gene enrichment
                      analysis. They showed major differences in the responses to
                      N starvation for transcription factor families, emmer showed
                      differential reduction in the levels of primary metabolites
                      while durum wheat exhibited increased levels of most of them
                      to N starvation. The correlation-based networks, including
                      the differentially expressed genes and metabolites, revealed
                      tighter regulation of metabolism in durum wheat in
                      comparison to emmer. We also found that glutamate and
                      γ-aminobutyric acid (GABA) had highest values of centrality
                      in the metabolic correlation network, suggesting their
                      critical role in the genotype-specific response to N
                      starvation of emmer and durum wheat, respectively. Moreover,
                      this finding indicates that there might be contrasting
                      strategies associated to GABA and glutamate signaling
                      modulating shoot vs. root growth in the two different wheat
                      subspecies},
      cin          = {IBG-2},
      ddc          = {540},
      cid          = {I:(DE-Juel1)IBG-2-20101118},
      pnm          = {2171 - Biological and environmental resources for
                      sustainable use (POF4-217)},
      pid          = {G:(DE-HGF)POF4-2171},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:33946478},
      UT           = {WOS:000650422800001},
      doi          = {10.3390/ijms22094790},
      url          = {https://juser.fz-juelich.de/record/904492},
}