TY  - JOUR
AU  - Rapan, Lucija
AU  - Niu, Meiqi
AU  - Zhao, Ling
AU  - Funck, Thomas
AU  - Amunts, Katrin
AU  - Zilles, Karl
AU  - Palomero-Gallagher, Nicola
TI  - Receptor architecture of macaque and human early visual areas: not equal, but comparable
JO  - Brain structure & function
VL  - 227
SN  - 0044-2232
CY  - Heidelberg
PB  - Springer
M1  - FZJ-2022-00040
SP  - 1247–1263
PY  - 2022
AB  - Existing cytoarchitectonic maps of the human and macaque posterior occipital cortex differ in the number of areas they display, thus hampering identification of homolog structures. We applied quantitative in vitro receptor autoradiography to characterize the receptor architecture of the primary visual and early extrastriate cortex in macaque and human brains, using previously published cytoarchitectonic criteria as starting point of our analysis. We identified 8 receptor architectonically distinct areas in the macaque brain (mV1d, mV1v, mV2d, mV2v, mV3d, mV3v, mV3A, mV4v), and their respective counterpart areas in the human brain (hV1d, hV1v, hV2d, hV2v, hV3d, hV3v, hV3A, hV4v). Mean densities of 14 neurotransmitter receptors were quantified in each area, and ensuing receptor fingerprints used for multivariate analyses. The 1st principal component segregated macaque and human early visual areas differ. However, the 2nd principal component showed that within each species, area-specific differences in receptor fingerprints were associated with the hierarchical processing level of each area. Subdivisions of V2 and V3 were found to cluster together in both species and were segregated from subdivisions of V1 and from V4v. Thus, comparative studies like this provide valuable architectonic insights into how differences in underlying microstructure impact evolutionary changes in functional processing of the primate brain and, at the same time, provide strong arguments for use of macaque monkey brain as a suitable animal model for translational studies.
LB  - PUB:(DE-HGF)16
C6  - pmid:34931262
UR  - <Go to ISI:>//WOS:000731815800001
DO  - DOI:10.1007/s00429-021-02437-y
UR  - https://juser.fz-juelich.de/record/904691
ER  -