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@ARTICLE{Chechko:904879,
      author       = {Chechko, Natalia and Lefort-Besnard, Jeremy and Goecke,
                      Tamme W. and Frensch, Markus and Schnakenberg, Patricia and
                      Stickel, Susanne and Bzdok, Danilo},
      title        = {{P}henotypical predictors of pregnancy-related restless
                      legs syndrome and their association with basal ganglia and
                      the limbic circuits},
      journal      = {Scientific reports},
      volume       = {11},
      number       = {1},
      issn         = {2045-2322},
      address      = {[London]},
      publisher    = {Macmillan Publishers Limited, part of Springer Nature},
      reportid     = {FZJ-2022-00195},
      pages        = {9996},
      year         = {2021},
      abstract     = {Restless legs syndrome (RLS) in pregnancy is a common
                      disorder with a multifactorial etiology. A neurological and
                      obstetrical cohort of 308 postpartum women was screened for
                      RLS within 1 to 6 days of childbirth and 12 weeks
                      postpartum. Of the 308 young mothers, 57 (prevalence rate
                      $19\%)$ were identified as having been affected by RLS
                      symptoms in the recently completed pregnancy. Structural and
                      functional MRI was obtained from 25 of these 57
                      participants. A multivariate two-window algorithm was
                      employed to systematically chart the relationship between
                      brain structures and phenotypical predictors of RLS. A
                      decreased volume of the parietal, orbitofrontal and frontal
                      areas shortly after delivery was found to be linked to
                      persistent RLS symptoms up to 12 weeks postpartum, the
                      symptoms' severity and intensity in the most recent
                      pregnancy, and a history of RLS in previous pregnancies. The
                      same negative relationship was observed between brain volume
                      and not being married, not receiving any iron supplement and
                      higher numbers of stressful life events. High cortisol
                      levels, being married and receiving iron supplements, on the
                      other hand, were found to be associated with increased
                      volumes in the bilateral striatum. Investigating RLS
                      symptoms in pregnancy within a brain-phenotype framework may
                      help shed light on the heterogeneity of the condition.},
      cin          = {INM-7},
      ddc          = {600},
      cid          = {I:(DE-Juel1)INM-7-20090406},
      pnm          = {5251 - Multilevel Brain Organization and Variability
                      (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5251},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {33976261},
      UT           = {WOS:000658810900005},
      doi          = {10.1038/s41598-021-89360-8},
      url          = {https://juser.fz-juelich.de/record/904879},
}