TY  - JOUR
AU  - Tiso, Till
AU  - Winter, Benedikt
AU  - Wei, Ren
AU  - Hee, Johann
AU  - de Witt, Jan
AU  - Wierckx, Nick
AU  - Quicker, Peter
AU  - Bornscheuer, Uwe T.
AU  - Bardow, André
AU  - Nogales, Juan
AU  - Blank, Lars M.
TI  - The metabolic potential of plastics as biotechnological carbon sources – Review and targets for the future
JO  - Metabolic engineering
VL  - 71
SN  - 1096-7176
CY  - Orlando, Fla.
PB  - Academic Press
M1  - FZJ-2022-00201
SP  - 77-98
PY  - 2022
N1  - Biotechnologie 1
AB  - The plastic crisis requires drastic measures, especially for the plastics’ end-of-life. Mixed plastic fractions are currently difficult to recycle, but microbial metabolism might open new pathways. With new technologies for degradation of plastics to oligo- and monomers, these carbon sources can be used in biotechnology for the upcycling of plastic waste to valuable products, such as bioplastics and biosurfactants. We briefly summarize well-known monomer degradation pathways and computed their theoretical yields for industrially interesting products. With this information in hand, we calculated replacement scenarios of existing fossil-based synthesis routes for the same products. Thereby, we highlight fossil-based products for which plastic monomers might be attractive alternative carbon sources. Notably, not the highest yield of product on substrate of the biochemical route, but rather the (in-)efficiency of the petrochemical routes (i.e., carbon, energy use) determines the potential of biochemical plastic upcycling. Our results might serve as a guide for future metabolic engineering efforts towards a sustainable plastic economy.
LB  - PUB:(DE-HGF)16
UR  - <Go to ISI:>//WOS:000793785100004
DO  - DOI:10.1016/j.ymben.2021.12.006
UR  - https://juser.fz-juelich.de/record/904885
ER  -