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100 1 _ |a Tiso, Till
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245 _ _ |a The metabolic potential of plastics as biotechnological carbon sources – Review and targets for the future
260 _ _ |a Orlando, Fla.
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500 _ _ |a Biotechnologie 1
520 _ _ |a The plastic crisis requires drastic measures, especially for the plastics’ end-of-life. Mixed plastic fractions are currently difficult to recycle, but microbial metabolism might open new pathways. With new technologies for degradation of plastics to oligo- and monomers, these carbon sources can be used in biotechnology for the upcycling of plastic waste to valuable products, such as bioplastics and biosurfactants. We briefly summarize well-known monomer degradation pathways and computed their theoretical yields for industrially interesting products. With this information in hand, we calculated replacement scenarios of existing fossil-based synthesis routes for the same products. Thereby, we highlight fossil-based products for which plastic monomers might be attractive alternative carbon sources. Notably, not the highest yield of product on substrate of the biochemical route, but rather the (in-)efficiency of the petrochemical routes (i.e., carbon, energy use) determines the potential of biochemical plastic upcycling. Our results might serve as a guide for future metabolic engineering efforts towards a sustainable plastic economy.
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700 1 _ |a Winter, Benedikt
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700 1 _ |a Wei, Ren
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700 1 _ |a Hee, Johann
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700 1 _ |a de Witt, Jan
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700 1 _ |a Wierckx, Nick
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700 1 _ |a Quicker, Peter
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700 1 _ |a Bornscheuer, Uwe T.
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700 1 _ |a Bardow, André
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700 1 _ |a Nogales, Juan
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700 1 _ |a Blank, Lars M.
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773 _ _ |a 10.1016/j.ymben.2021.12.006
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856 4 _ |u https://juser.fz-juelich.de/record/904885/files/Tiso%20et%20al%202022%20Metab%20Eng%2071%2077-98.pdf
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