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000904971 1001_ $$0P:(DE-HGF)0$$aYamaguchi, Takahide$$b0
000904971 245__ $$aOpen-Bundle Structure as the Unfolding Intermediate of Cytochrome c′ Revealed by Small Angle Neutron Scattering
000904971 260__ $$aBasel$$bMDPI$$c2022
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000904971 520__ $$aThe dynamic structure changes, including the unfolding, dimerization, and transition from the compact to the open-bundle unfolding intermediate structure of Cyt c', were detected by a small-angle neutron scattering experiment (SANS). The structure of Cyt c' was changed into an unstructured random coil at pD = 1.7 (Rg = 25 Å for the Cyt c' monomer). The four-α-helix bundle structure of Cyt c' at neutral pH was transitioned to an open-bundle structure (at pD ~13), which is given by a numerical partial scattering function analysis as a joint-clubs model consisting of four clubs (α-helices) connected by short loops. The compactly folded structure of Cyt c' (radius of gyration, Rg = 18 Å for the Cyt c' dimer) at neutral or mildly alkaline pD transited to a remarkably larger open-bundle structure at pD ~13 (Rg = 25 Å for the Cyt c' monomer). The open-bundle structure was also supported by ab initio modeling.
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000904971 65017 $$0V:(DE-MLZ)GC-1602-2016$$2V:(DE-HGF)$$aPolymers, Soft Nano Particles and  Proteins$$x0
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000904971 7001_ $$0P:(DE-HGF)0$$aAkao, Kouhei$$b1
000904971 7001_ $$0P:(DE-Juel1)158075$$aKoutsioubas, Alexandros$$b2
000904971 7001_ $$0P:(DE-Juel1)130646$$aFrielinghaus, Henrich$$b3
000904971 7001_ $$00000-0002-5637-1682$$aKohzuma, Takamitsu$$b4$$eCorresponding author
000904971 773__ $$0PERI:(DE-600)2701262-1$$a10.3390/biom12010095$$gVol. 12, no. 1, p. 95 -$$n1$$p95 -$$tBiomolecules$$v12$$x2218-273X$$y2022
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