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000905084 1001_ $$0P:(DE-HGF)0$$aBaur, Diego M.$$b0
000905084 245__ $$aCoffee effectively attenuates impaired attention in ADORA2A C/C-allele carriers during chronic sleep restriction
000905084 260__ $$aAmsterdam [u.a.]$$bElsevier Science$$c2021
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000905084 520__ $$aMany people consume coffee to attenuate increased sleepiness and impaired vigilance and attention due to insufficient sleep. We investigated in genetically caffeine sensitive men and women whether ‘real world’ coffee consumption during a simulated busy work week counteracts disabling consequences of chronically restricted sleep. We subjected homozygous C-allele carriers of ADORA2A (gene encoding adenosine A2A receptors) to five nights of only 5 h time-in-bed. We administered regular coffee (n = 12; 200 mg caffeine at breakfast and 100 mg caffeine after lunch) and decaffeinated coffee (n = 14) in double-blind fashion on all days following sleep restriction. At regular intervals four times each day, participants rated their sleepiness and performed the psychomotor vigilance test, the visual search task, and the visuo-spatial and letter n-back tasks. At bedtime, we quantified caffeine and the major caffeine metabolites paraxanthine, theobromine and theophylline in saliva. The two groups did not differ in age, body-mass-index, sex-ratio, chronotype and mood states. Subjective sleepiness increased in both groups across consecutive sleep restriction days and did not differ. By contrast, regular coffee counteracted the impact of repeated sleep loss on sustained and selective attention, as well as executive control when compared to decaffeinated coffee. The coffee also induced initial or transient benefits on different aspects of baseline performance during insufficient sleep. All differences between the groups disappeared after the recovery night and the cessation of coffee administration. The data suggest that ‘real world’ coffee consumption can efficiently attenuate sleep restriction-induced impairments in vigilance and attention in genetically caffeine sensitive individuals.
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000905084 65017 $$0V:(DE-MLZ)GC-130-2016$$2V:(DE-HGF)$$aHealth and Life$$x0
000905084 7001_ $$0P:(DE-Juel1)165827$$aLange, Denise$$b1
000905084 7001_ $$0P:(DE-HGF)0$$aElmenhorst, Eva-Maria$$b2
000905084 7001_ $$0P:(DE-Juel1)131679$$aElmenhorst, David$$b3
000905084 7001_ $$0P:(DE-Juel1)131672$$aBauer, Andreas$$b4$$ufzj
000905084 7001_ $$0P:(DE-HGF)0$$aAeschbach, Daniel$$b5
000905084 7001_ $$0P:(DE-HGF)0$$aLandolt, Hans-Peter$$b6$$eCorresponding author
000905084 773__ $$0PERI:(DE-600)2008803-6$$a10.1016/j.pnpbp.2020.110232$$gVol. 109, p. 110232 -$$p110232 -$$tProgress in neuro-psychopharmacology & biological psychiatry$$v109$$x0278-5846$$y2021
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000905084 9101_ $$0I:(DE-HGF)0$$6P:(DE-HGF)0$$a Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland$$b0
000905084 9101_ $$0I:(DE-HGF)0$$6P:(DE-HGF)0$$a Sleep & Health Zurich, University Center of Competence, University of Zurich, Zurich, Switzerland$$b0
000905084 9101_ $$0I:(DE-HGF)0$$6P:(DE-Juel1)165827$$a Department of Sleep and Human Factors, Institute of Aerospace Medicine, German Aerospace Center, Cologne, Germany$$b1
000905084 9101_ $$0I:(DE-HGF)0$$6P:(DE-Juel1)131679$$a Faculty of Medicine, University of Bonn, Bonn, Germany$$b3
000905084 9101_ $$0I:(DE-HGF)0$$6P:(DE-Juel1)131679$$a Institute of Neuroscience and Medicine, Forschungszentrum Jülich, Jülich, Germany$$b3
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000905084 9101_ $$0I:(DE-HGF)0$$6P:(DE-HGF)0$$a Faculty of Medicine, University of Bonn, Bonn, Germany$$b5
000905084 9101_ $$0I:(DE-HGF)0$$6P:(DE-HGF)0$$a Department of Sleep and Human Factors, Institute of Aerospace Medicine, German Aerospace Center, Cologne, Germany$$b5
000905084 9101_ $$0I:(DE-HGF)0$$6P:(DE-HGF)0$$a Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland$$b6
000905084 9101_ $$0I:(DE-HGF)0$$6P:(DE-HGF)0$$a Sleep & Health Zurich, University Center of Competence, University of Zurich, Zurich, Switzerland$$b6
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