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@ARTICLE{Baur:905084,
      author       = {Baur, Diego M. and Lange, Denise and Elmenhorst, Eva-Maria
                      and Elmenhorst, David and Bauer, Andreas and Aeschbach,
                      Daniel and Landolt, Hans-Peter},
      title        = {{C}offee effectively attenuates impaired attention in
                      {ADORA}2{A} {C}/{C}-allele carriers during chronic sleep
                      restriction},
      journal      = {Progress in neuro-psychopharmacology $\&$ biological
                      psychiatry},
      volume       = {109},
      issn         = {0278-5846},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {FZJ-2022-00383},
      pages        = {110232 -},
      year         = {2021},
      abstract     = {Many people consume coffee to attenuate increased
                      sleepiness and impaired vigilance and attention due to
                      insufficient sleep. We investigated in genetically caffeine
                      sensitive men and women whether ‘real world’ coffee
                      consumption during a simulated busy work week counteracts
                      disabling consequences of chronically restricted sleep. We
                      subjected homozygous C-allele carriers of ADORA2A (gene
                      encoding adenosine A2A receptors) to five nights of only 5 h
                      time-in-bed. We administered regular coffee (n = 12; 200 mg
                      caffeine at breakfast and 100 mg caffeine after lunch) and
                      decaffeinated coffee (n = 14) in double-blind fashion on all
                      days following sleep restriction. At regular intervals four
                      times each day, participants rated their sleepiness and
                      performed the psychomotor vigilance test, the visual search
                      task, and the visuo-spatial and letter n-back tasks. At
                      bedtime, we quantified caffeine and the major caffeine
                      metabolites paraxanthine, theobromine and theophylline in
                      saliva. The two groups did not differ in age,
                      body-mass-index, sex-ratio, chronotype and mood states.
                      Subjective sleepiness increased in both groups across
                      consecutive sleep restriction days and did not differ. By
                      contrast, regular coffee counteracted the impact of repeated
                      sleep loss on sustained and selective attention, as well as
                      executive control when compared to decaffeinated coffee. The
                      coffee also induced initial or transient benefits on
                      different aspects of baseline performance during
                      insufficient sleep. All differences between the groups
                      disappeared after the recovery night and the cessation of
                      coffee administration. The data suggest that ‘real
                      world’ coffee consumption can efficiently attenuate sleep
                      restriction-induced impairments in vigilance and attention
                      in genetically caffeine sensitive individuals.},
      cin          = {INM-2},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-2-20090406},
      pnm          = {5252 - Brain Dysfunction and Plasticity (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5252},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {33373678},
      UT           = {WOS:000663332600001},
      doi          = {10.1016/j.pnpbp.2020.110232},
      url          = {https://juser.fz-juelich.de/record/905084},
}