% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@INPROCEEDINGS{Patil:905260,
      author       = {Patil, Kaustubh and Popovych, Oleksandr and Jain, Shraddha},
      title        = {{G}ender {D}ifferences in {E}mpirical and {S}imulated
                      {B}rain {C}onnectomes},
      reportid     = {FZJ-2022-00543},
      year         = {2021},
      abstract     = {Investigating gender differences in brain connectomes has
                      been an active area of research in neuroscience. Previous
                      studies have, however, explored only the empirical
                      connectomes. This projectconsiders simulated brain
                      connectomes generated by whole-brain dynamical models and
                      their correlation with the empirical connectomes to
                      investigate gender differences. The analysis involves
                      272subjects from the human connectome project (144 females).
                      For each individual and 11 brain parcellation schemes, we
                      calculated an empirical structural connectivity (eSC), an
                      empirical functionalconnectivity (eFC) of the resting-state
                      fMRI BOLD signals and two simulated functional
                      connectivity(sFC) matrices based on the ensembles of coupled
                      phase- (PO) and limit-cycle (LC) oscillators. Thegender
                      difference was then investigated using the Wilcoxon sum
                      ranks test of the Pearson’s correlation coefficient
                      corr(sFC, eFC) between the simulated and the empirical
                      functional connectomes. Weobserved a significantly higher
                      correlation for males for 11 parcellations. Since the models
                      utilizethe empirical information, we regressed out the brain
                      size and empirical structure-function relationship corr(eFC,
                      eSC), to check if the gender difference still persists.
                      After the regression, thisdifference remains significant for
                      10 atlases for PO model and for 8 atlases for LC model.
                      Interestingly, the gender difference in corr(eFC, eSC)
                      showed an opposite trend - the females showed a
                      betterstructure-function correspondence than males. This is
                      in contrast with the modeling results, wherea better fit
                      between sFC and eFC is observed for males. A potential
                      reason for this discrepancy couldbe the difference in
                      complexity of the empirical data between genders, which in
                      turn may influencethe quality of the model fitting. The
                      project currently aims to examine this in more detail.},
      month         = {Oct},
      date          = {2021-10-05},
      organization  = {INM $\&$ IBI Retreat 2021,
                       Forschungszentrum Jülich, Virtual
                       Conference (Germany), 5 Oct 2021 - 6
                       Oct 2021},
      subtyp        = {After Call},
      cin          = {INM-7},
      cid          = {I:(DE-Juel1)INM-7-20090406},
      pnm          = {5232 - Computational Principles (POF4-523) / 5231 -
                      Neuroscientific Foundations (POF4-523) / 5254 -
                      Neuroscientific Data Analytics and AI (POF4-525) / HBP SGA2
                      - Human Brain Project Specific Grant Agreement 2 (785907) /
                      HBP SGA3 - Human Brain Project Specific Grant Agreement 3
                      (945539) / VirtualBrainCloud - Personalized Recommendations
                      for Neurodegenerative Disease (826421)},
      pid          = {G:(DE-HGF)POF4-5232 / G:(DE-HGF)POF4-5231 /
                      G:(DE-HGF)POF4-5254 / G:(EU-Grant)785907 /
                      G:(EU-Grant)945539 / G:(EU-Grant)826421},
      typ          = {PUB:(DE-HGF)24},
      url          = {https://juser.fz-juelich.de/record/905260},
}