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000905317 005__ 20220131120325.0
000905317 037__ $$aFZJ-2022-00588
000905317 1001_ $$0P:(DE-Juel1)178767$$aMaleki Balajoo, Somayeh$$b0$$eCorresponding author$$ufzj
000905317 1112_ $$aNM & IBI Retreat$$cVirtual$$d2021-10-05 - 2021-10-06$$wGermany
000905317 245__ $$aHippocampal metabolic subregions and networks: behavioral, molecular and pathological aging profiles
000905317 260__ $$c2021
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000905317 520__ $$aHippocampal dysfunction happens across many neuropsychiatric disorders and is the hallmark of Alzheimer’s disease (AD) with evidenced metabolic alterations. Based on hippocampal-brain metabolic covariance in a healthy elderly cohort, we found a differentiation into primarily anterior vs. posterior and secondarily CA vs. subiculum subregions. Characterizing the associated metabolic networks revealed that the anterior-subiculum network including temporal-pole and orbitofrontal regions relates to self, motivation and mentalizing behavior and is influenced by dopaminergic systems. In contrast, the posterior-subiculum shows a wide cortical network engaged in action- and world-oriented cognition targeted by serotoninergic systems. The anterior- and posterior-CA, connected respectively to amygdala and broader subcortical networks, are associated to several transporters release. Local metabolism comparison between AD-related diagnosis groups revealed early CA’s alterations while posterior subicular alterations appear at advanced stages in line with broader cortical atrophy and behavioral dysfunctions. Future studies should delineate patients’ individual profiles according to hippocampal subregions and networks.
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000905317 7001_ $$0P:(DE-Juel1)131678$$aEickhoff, Simon$$b1$$ufzj
000905317 7001_ $$0P:(DE-Juel1)171719$$aKharabian, Shahrzad$$b2$$ufzj
000905317 7001_ $$0P:(DE-Juel1)167223$$aPlachti, Anna$$b3$$ufzj
000905317 7001_ $$0P:(DE-Juel1)178653$$aWaite, Laura$$b4$$ufzj
000905317 7001_ $$0P:(DE-Juel1)131684$$aHoffstaedter, Felix$$b5$$ufzj
000905317 7001_ $$0P:(DE-Juel1)131701$$aPalomero-Gallagher, Nicola$$b6$$ufzj
000905317 7001_ $$0P:(DE-Juel1)161225$$aGENON, Sarah$$b7$$ufzj
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