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@INPROCEEDINGS{MalekiBalajoo:905317,
      author       = {Maleki Balajoo, Somayeh and Eickhoff, Simon and Kharabian,
                      Shahrzad and Plachti, Anna and Waite, Laura and
                      Hoffstaedter, Felix and Palomero-Gallagher, Nicola and
                      GENON, Sarah},
      title        = {{H}ippocampal metabolic subregions and networks:
                      behavioral, molecular and pathological aging profiles},
      reportid     = {FZJ-2022-00588},
      year         = {2021},
      abstract     = {Hippocampal dysfunction happens across many
                      neuropsychiatric disorders and is the hallmark of
                      Alzheimer’s disease (AD) with evidenced metabolic
                      alterations. Based on hippocampal-brain metabolic covariance
                      in a healthy elderly cohort, we found a differentiation into
                      primarily anterior vs. posterior and secondarily CA vs.
                      subiculum subregions. Characterizing the associated
                      metabolic networks revealed that the anterior-subiculum
                      network including temporal-pole and orbitofrontal regions
                      relates to self, motivation and mentalizing behavior and is
                      influenced by dopaminergic systems. In contrast, the
                      posterior-subiculum shows a wide cortical network engaged in
                      action- and world-oriented cognition targeted by
                      serotoninergic systems. The anterior- and posterior-CA,
                      connected respectively to amygdala and broader subcortical
                      networks, are associated to several transporters release.
                      Local metabolism comparison between AD-related diagnosis
                      groups revealed early CA’s alterations while posterior
                      subicular alterations appear at advanced stages in line with
                      broader cortical atrophy and behavioral dysfunctions. Future
                      studies should delineate patients’ individual profiles
                      according to hippocampal subregions and networks.},
      month         = {Oct},
      date          = {2021-10-05},
      organization  = {NM $\&$ IBI Retreat, Virtual
                       (Germany), 5 Oct 2021 - 6 Oct 2021},
      cin          = {INM-7},
      cid          = {I:(DE-Juel1)INM-7-20090406},
      pnm          = {5251 - Multilevel Brain Organization and Variability
                      (POF4-525) / 5252 - Brain Dysfunction and Plasticity
                      (POF4-525) / 5253 - Neuroimaging (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5251 / G:(DE-HGF)POF4-5252 /
                      G:(DE-HGF)POF4-5253},
      typ          = {PUB:(DE-HGF)1},
      url          = {https://juser.fz-juelich.de/record/905317},
}