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@ARTICLE{Roe:905341,
      author       = {Roe, James M. and Vidal-Piñeiro, Didac and Amlien, Inge K.
                      and Pan, Mengyu and Sneve, Markus H. and de Schotten, Michel
                      Thiebaut and Friedrich, Patrick and Sha, Zhiqiang and
                      Francks, Clyde and Wang, Yunpeng and Walhovd, Kristine B.
                      and Fjell, Anders M. and Westerhausen, René},
      title        = {{P}opulation-level asymmetry of the cerebral cortex:
                      reproducibility, lifespan changes, heritability, and
                      individual differences},
      reportid     = {FZJ-2022-00609},
      year         = {2021},
      abstract     = {Cortical asymmetry is a ubiquitous feature of brain
                      organization that is altered in neurodevelopmental disorders
                      and aging. Achieving consensus on cortical asymmetries in
                      humans is necessary to uncover the genetic-developmental
                      mechanisms that shape them and factors moderating cortical
                      lateralization. Here, we delineate population-level
                      asymmetry in cortical thickness and surface area vertex-wise
                      in 7 datasets and chart asymmetry trajectories across life
                      (4-89 years; observations = 3937; $70\%$ longitudinal). We
                      reveal asymmetry interrelationships, heritability, and test
                      associations in UK Biobank (N=~37,500). Cortical asymmetry
                      was robust across datasets. Whereas areal asymmetry is
                      predominantly stable across life, thickness asymmetry grows
                      in development and declines in aging. Areal asymmetry
                      correlates in specific regions, whereas thickness asymmetry
                      is globally interrelated across cortex and suggests high
                      directional variability in global thickness lateralization.
                      Areal asymmetry is moderately heritable (max h 2 SNP
                      $~19\%),$ and phenotypic correlations are reflected by high
                      genetic correlations, whereas heritability of thickness
                      asymmetry is low. Finally, we detected an asymmetry
                      association with cognition and confirm recently-reported
                      handedness links. Results suggest areal asymmetry is
                      developmentally stable and arises in early life, whereas
                      developmental changes in thickness asymmetry may lead to
                      directional variability of global thickness lateralization.
                      Our results bear enough reproducibility to serve as a
                      standard for future brain asymmetry studies.},
      cin          = {INM-7},
      cid          = {I:(DE-Juel1)INM-7-20090406},
      pnm          = {5251 - Multilevel Brain Organization and Variability
                      (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5251},
      typ          = {PUB:(DE-HGF)25},
      doi          = {10.1101/2021.11.25.469988},
      url          = {https://juser.fz-juelich.de/record/905341},
}