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@ARTICLE{Bocharov:905388,
author = {Bocharov, Eduard V. and Gremer, Lothar and Urban, Anatoly
S. and Okhrimenko, Ivan S. and Volynsky, Pavel E. and
Nadezhdin, Kirill D. and Bocharova, Olga V. and Kornilov,
Daniil A. and Zagryadskaya, Yuliya A. and Kamynina, Anna V.
and Kuzmichev, Pavel K. and Kutzsche, Janine and Bolakhrif,
Najoua and Müller-Schiffmann, Andreas and Dencher, Norbert
A. and Arseniev, Alexander S. and Efremov, Roman G. and
Gordeliy, Valentin I. and Willbold, Dieter},
title = {{A}ll - d - {E}nantiomeric {P}eptide {D}3 {D}esigned for
{A}lzheimer’s {D}isease {T}reatment {D}ynamically
{I}nteracts with {M}embrane-{B}ound {A}myloid-β
{P}recursors},
journal = {Journal of medicinal chemistry},
volume = {64},
number = {22},
issn = {0022-2623},
address = {Washington, DC},
publisher = {ACS},
reportid = {FZJ-2022-00640},
pages = {16464 - 16479},
year = {2021},
note = {Kein Post-print vorhanden},
abstract = {Alzheimer’s disease (AD) is a severe neurodegenerative
pathology with no effective treatment known. Toxic
amyloid-β peptide (Aβ) oligomers play a crucial role in AD
pathogenesis. All-d-Enantiomeric peptide D3 and its
derivatives were developed to disassemble and destroy
cytotoxic Aβ aggregates. One of the D3-like compounds is
approaching phase II clinical trials; however,
high-resolution details of its disease-preventing or
pharmacological actions are not completely clear. We
demonstrate that peptide D3 stabilizing Aβ monomer
dynamically interacts with the extracellular juxtamembrane
region of a membrane-bound fragment of an amyloid precursor
protein containing the Aβ sequence. MD simulations based on
NMR measurement results suggest that D3 targets the
amyloidogenic region, not compromising its α-helicity and
preventing intermolecular hydrogen bonding, thus creating
prerequisites for inhibition of early steps of Aβ
conversion into β-conformation and its toxic
oligomerization. An enhanced understanding of the D3 action
molecular mechanism facilitates development of effective AD
treatment and prevention strategies.},
cin = {IBI-7},
ddc = {610},
cid = {I:(DE-Juel1)IBI-7-20200312},
pnm = {5244 - Information Processing in Neuronal Networks
(POF4-524)},
pid = {G:(DE-HGF)POF4-5244},
typ = {PUB:(DE-HGF)16},
pubmed = {pmid:34739758},
UT = {WOS:000754726000008},
doi = {10.1021/acs.jmedchem.1c00632},
url = {https://juser.fz-juelich.de/record/905388},
}