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@INPROCEEDINGS{Hahn:905419,
      author       = {Hahn, Lisa and Eickhoff, Simon and Consortium, German FTLD
                      and Otto, Markus and Dukart, Jürgen and Schroeter,
                      Matthias},
      title        = {{R}esting-state alterations in behavioral variant
                      frontotemporal dementia are related to the distribution of
                      monoamine and {GABA} neurotransmitter systems},
      reportid     = {FZJ-2022-00660},
      year         = {2021},
      abstract     = {Introduction: Aside to changes in personality and behavior,
                      behavioral variant frontotemporal dementia (bvFTD) is
                      characterized by progressive structural and functional
                      alterations in frontal and temporal regions. Only little is
                      known about the underlying mechanisms leading to the
                      anatomical constraints of the pathophysiology. Here, we
                      evaluated if these alterations are linked to the
                      distribution of specific neurotransmitter systems.Methods:
                      Maps of fractional amplitude of low frequency fluctuations
                      (fALFF) were derived as a measure of local activity from
                      resting state functional magnetic resonance imaging for 52
                      bvFTD patients and 22 healthy controls (HC). We tested if
                      alterations in the fALFF signal of bvFTD patients
                      co-localize with the known non-pathological distribution of
                      specific neurotransmitter systems and their coding mRNA gene
                      expression. Furthermore, we evaluated if the strength of
                      this co-localization is associated with respective symptom
                      severity.Results: Compared to HC, patients displayed
                      significantly reduced fractional amplitude of low frequency
                      fluctuations in fronto-temporal and fronto-parietal regions.
                      These alterations significantly co-localized with the
                      distribution of serotonin (5-HT1b, 5-HT2a), dopamine (D2),
                      and gamma-aminobutyric acid type A receptors, the
                      noradrenaline transporter, and their encoding mRNA gene
                      expression. The strength of the co-localization with D2 and
                      noradrenaline transporter was associated with cognitive
                      symptoms of bvFTD. Conclusion: Local brain functional
                      activity reductions in bvFTD follow the distribution of
                      specific neurotransmitter systems supporting the notion of
                      the preferential vulnerability of specific neurotransmitter
                      systems. These findings provide novel insight into
                      neuropathophysiological mechanisms underlying functional
                      alterations in bvFTD.},
      month         = {Nov},
      date          = {2021-11-24},
      organization  = {DGPPN Kongress, Berlin (Germany), 24
                       Nov 2021 - 27 Nov 2021},
      subtyp        = {After Call},
      cin          = {INM-7},
      cid          = {I:(DE-Juel1)INM-7-20090406},
      pnm          = {5253 - Neuroimaging (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5253},
      typ          = {PUB:(DE-HGF)6},
      url          = {https://juser.fz-juelich.de/record/905419},
}