000905420 001__ 905420
000905420 005__ 20220131120330.0
000905420 0247_ $$2Handle$$a2128/30340
000905420 037__ $$aFZJ-2022-00661
000905420 041__ $$aEnglish
000905420 1001_ $$0P:(DE-Juel1)177012$$aHahn, Lisa$$b0$$eFirst author$$ufzj
000905420 1112_ $$aSociety of Biological Psychiatry 2021 Annual Meeting$$cOnline$$d2021-04-28 - 2021-05-01$$gSOBP$$wUSA
000905420 245__ $$aResting-state alterations in behavioral variant frontotemporal dementia are related to the distribution of monoamine and GABA neurotransmitter systems
000905420 260__ $$c2021
000905420 3367_ $$033$$2EndNote$$aConference Paper
000905420 3367_ $$2BibTeX$$aINPROCEEDINGS
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000905420 520__ $$aBackground: Behavioral variant frontotemporal dementia (bvFTD) is characterized by changes in personality and behavior and by progressive structural and functional alterations in frontal and temporal regions. Only little is known about the relationship of these alterations with the underlying pathophysiology. Here, we explored if these alterations follow the distribution of specific neurotransmitter systems.Methods: We evaluated if resting state activity alterations in bvFTD are associated with the known in vivo distribution of specific neurotransmitter systems. For this, maps of fractional amplitude of low frequency fluctuations (fALFF) as derived from resting-state functional magnetic resonance imaging were computed for 52 bvFTD patients relative to 22 healthy controls (HC). We tested if these maps co-localize with the non-pathological distribution of specific neurotransmitter systems and their coding mRNA gene expression.Results: Compared to HC, patients displayed significantly reduced fALFF in fronto-temporal and fronto-parietal regions. These alterations significantly co-localized with the distribution of serotonin (5HT1b, 5HT2a), dopamine (D2), and gamma-aminobutyric acid type A (GABAa) receptors, and the noradrenaline transporter (NAT) (all p≤.001). Significant co-localization of fALFF alterations was also observed with mRNA expression of genes encoding the respective receptors and transporters.Conclusion: We showed that fALFF reduction in bvFTD co-localize with the spatial distribution of serotonergic, dopaminergic, GABAergic, and noradrenalinergic systems, and their coding mRNA gene expression. These findings provide novel insight into neuropathophysiological mechanisms underlying functional alterations in bvFTD.
000905420 536__ $$0G:(DE-HGF)POF4-5253$$a5253 - Neuroimaging (POF4-525)$$cPOF4-525$$fPOF IV$$x0
000905420 7001_ $$0P:(DE-Juel1)131678$$aEickhoff, Simon$$b1$$ufzj
000905420 7001_ $$0P:(DE-HGF)0$$aOtto, Markus$$b2
000905420 7001_ $$0P:(DE-Juel1)177727$$aDukart, Jürgen$$b3$$eCorresponding author$$ufzj
000905420 7001_ $$0P:(DE-HGF)0$$aSchroeter, Matthias L.$$b4$$eCorresponding author
000905420 8564_ $$uhttps://juser.fz-juelich.de/record/905420/files/Poster-1.pdf$$yOpenAccess
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000905420 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)177012$$aForschungszentrum Jülich$$b0$$kFZJ
000905420 9101_ $$0I:(DE-HGF)0$$6P:(DE-Juel1)177012$$a Institute of Systems Neuroscience, Heinrich Heine University Düsseldorf, Germany$$b0
000905420 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)131678$$aForschungszentrum Jülich$$b1$$kFZJ
000905420 9101_ $$0I:(DE-HGF)0$$6P:(DE-Juel1)131678$$a Institute of Systems Neuroscience, Heinrich Heine University Düsseldorf, Germany$$b1
000905420 9101_ $$0I:(DE-HGF)0$$6P:(DE-HGF)0$$a Department of Neurology, Ulm University, Ulm, Baden Württemberg, Germany$$b2
000905420 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)177727$$aForschungszentrum Jülich$$b3$$kFZJ
000905420 9101_ $$0I:(DE-HGF)0$$6P:(DE-Juel1)177727$$a Institute of Systems Neuroscience, Heinrich Heine University Düsseldorf, Germany$$b3
000905420 9101_ $$0I:(DE-HGF)0$$6P:(DE-HGF)0$$a Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences , Leipzig, Germany$$b4
000905420 9101_ $$0I:(DE-HGF)0$$6P:(DE-HGF)0$$a Clinic for Cognitive Neurology, University Hospital Leipzig, Germany$$b4
000905420 9131_ $$0G:(DE-HGF)POF4-525$$1G:(DE-HGF)POF4-520$$2G:(DE-HGF)POF4-500$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$9G:(DE-HGF)POF4-5253$$aDE-HGF$$bKey Technologies$$lNatural, Artificial and Cognitive Information Processing$$vDecoding Brain Organization and Dysfunction$$x0
000905420 9141_ $$y2021
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