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@INPROCEEDINGS{Hahn:905420,
      author       = {Hahn, Lisa and Eickhoff, Simon and Otto, Markus and Dukart,
                      Jürgen and Schroeter, Matthias L.},
      title        = {{R}esting-state alterations in behavioral variant
                      frontotemporal dementia are related to the distribution of
                      monoamine and {GABA} neurotransmitter systems},
      reportid     = {FZJ-2022-00661},
      year         = {2021},
      abstract     = {Background: Behavioral variant frontotemporal dementia
                      (bvFTD) is characterized by changes in personality and
                      behavior and by progressive structural and functional
                      alterations in frontal and temporal regions. Only little is
                      known about the relationship of these alterations with the
                      underlying pathophysiology. Here, we explored if these
                      alterations follow the distribution of specific
                      neurotransmitter systems.Methods: We evaluated if resting
                      state activity alterations in bvFTD are associated with the
                      known in vivo distribution of specific neurotransmitter
                      systems. For this, maps of fractional amplitude of low
                      frequency fluctuations (fALFF) as derived from resting-state
                      functional magnetic resonance imaging were computed for 52
                      bvFTD patients relative to 22 healthy controls (HC). We
                      tested if these maps co-localize with the non-pathological
                      distribution of specific neurotransmitter systems and their
                      coding mRNA gene expression.Results: Compared to HC,
                      patients displayed significantly reduced fALFF in
                      fronto-temporal and fronto-parietal regions. These
                      alterations significantly co-localized with the distribution
                      of serotonin (5HT1b, 5HT2a), dopamine (D2), and
                      gamma-aminobutyric acid type A (GABAa) receptors, and the
                      noradrenaline transporter (NAT) (all p≤.001). Significant
                      co-localization of fALFF alterations was also observed with
                      mRNA expression of genes encoding the respective receptors
                      and transporters.Conclusion: We showed that fALFF reduction
                      in bvFTD co-localize with the spatial distribution of
                      serotonergic, dopaminergic, GABAergic, and noradrenalinergic
                      systems, and their coding mRNA gene expression. These
                      findings provide novel insight into neuropathophysiological
                      mechanisms underlying functional alterations in bvFTD.},
      month         = {Apr},
      date          = {2021-04-28},
      organization  = {Society of Biological Psychiatry 2021
                       Annual Meeting, Online (USA), 28 Apr
                       2021 - 1 May 2021},
      subtyp        = {After Call},
      cin          = {INM-7},
      cid          = {I:(DE-Juel1)INM-7-20090406},
      pnm          = {5253 - Neuroimaging (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5253},
      typ          = {PUB:(DE-HGF)24},
      url          = {https://juser.fz-juelich.de/record/905420},
}