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| Home > Publications database > Resting-state alterations in behavioral variant frontotemporal dementia are related to the distribution of monoamine and GABA neurotransmitter systems > print |
| 001 | 905420 | ||
| 005 | 20220131120330.0 | ||
| 024 | 7 | _ | |a 2128/30340 |2 Handle |
| 037 | _ | _ | |a FZJ-2022-00661 |
| 041 | _ | _ | |a English |
| 100 | 1 | _ | |a Hahn, Lisa |0 P:(DE-Juel1)177012 |b 0 |e First author |u fzj |
| 111 | 2 | _ | |a Society of Biological Psychiatry 2021 Annual Meeting |g SOBP |c Online |d 2021-04-28 - 2021-05-01 |w USA |
| 245 | _ | _ | |a Resting-state alterations in behavioral variant frontotemporal dementia are related to the distribution of monoamine and GABA neurotransmitter systems |
| 260 | _ | _ | |c 2021 |
| 336 | 7 | _ | |a Conference Paper |0 33 |2 EndNote |
| 336 | 7 | _ | |a INPROCEEDINGS |2 BibTeX |
| 336 | 7 | _ | |a conferenceObject |2 DRIVER |
| 336 | 7 | _ | |a CONFERENCE_POSTER |2 ORCID |
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| 336 | 7 | _ | |a Poster |b poster |m poster |0 PUB:(DE-HGF)24 |s 1642508102_6597 |2 PUB:(DE-HGF) |x After Call |
| 520 | _ | _ | |a Background: Behavioral variant frontotemporal dementia (bvFTD) is characterized by changes in personality and behavior and by progressive structural and functional alterations in frontal and temporal regions. Only little is known about the relationship of these alterations with the underlying pathophysiology. Here, we explored if these alterations follow the distribution of specific neurotransmitter systems.Methods: We evaluated if resting state activity alterations in bvFTD are associated with the known in vivo distribution of specific neurotransmitter systems. For this, maps of fractional amplitude of low frequency fluctuations (fALFF) as derived from resting-state functional magnetic resonance imaging were computed for 52 bvFTD patients relative to 22 healthy controls (HC). We tested if these maps co-localize with the non-pathological distribution of specific neurotransmitter systems and their coding mRNA gene expression.Results: Compared to HC, patients displayed significantly reduced fALFF in fronto-temporal and fronto-parietal regions. These alterations significantly co-localized with the distribution of serotonin (5HT1b, 5HT2a), dopamine (D2), and gamma-aminobutyric acid type A (GABAa) receptors, and the noradrenaline transporter (NAT) (all p≤.001). Significant co-localization of fALFF alterations was also observed with mRNA expression of genes encoding the respective receptors and transporters.Conclusion: We showed that fALFF reduction in bvFTD co-localize with the spatial distribution of serotonergic, dopaminergic, GABAergic, and noradrenalinergic systems, and their coding mRNA gene expression. These findings provide novel insight into neuropathophysiological mechanisms underlying functional alterations in bvFTD. |
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| 700 | 1 | _ | |a Eickhoff, Simon |0 P:(DE-Juel1)131678 |b 1 |u fzj |
| 700 | 1 | _ | |a Otto, Markus |0 P:(DE-HGF)0 |b 2 |
| 700 | 1 | _ | |a Dukart, Jürgen |0 P:(DE-Juel1)177727 |b 3 |e Corresponding author |u fzj |
| 700 | 1 | _ | |a Schroeter, Matthias L. |0 P:(DE-HGF)0 |b 4 |e Corresponding author |
| 856 | 4 | _ | |u https://juser.fz-juelich.de/record/905420/files/Poster-1.pdf |y OpenAccess |
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| 910 | 1 | _ | |a Institute of Systems Neuroscience, Heinrich Heine University Düsseldorf, Germany |0 I:(DE-HGF)0 |b 0 |6 P:(DE-Juel1)177012 |
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| 910 | 1 | _ | |a Department of Neurology, Ulm University, Ulm, Baden Württemberg, Germany |0 I:(DE-HGF)0 |b 2 |6 P:(DE-HGF)0 |
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| 910 | 1 | _ | |a Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences , Leipzig, Germany |0 I:(DE-HGF)0 |b 4 |6 P:(DE-HGF)0 |
| 910 | 1 | _ | |a Clinic for Cognitive Neurology, University Hospital Leipzig, Germany |0 I:(DE-HGF)0 |b 4 |6 P:(DE-HGF)0 |
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| 914 | 1 | _ | |y 2021 |
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