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@ARTICLE{VosdeWael:905746,
author = {Vos de Wael, Reinder and Royer, Jessica and Tavakol, Shahin
and Wang, Yezhou and Paquola, Casey and Benkarim, Oualid and
Eichert, Nicole and Larivière, Sara and Xu, Ting and Misic,
Bratislav and Smallwood, Jonathan and Valk, Sofie L and
Bernhardt, Boris C},
title = {{S}tructural {C}onnectivity {G}radients of the {T}emporal
{L}obe {S}erve as {M}ultiscale {A}xes of {B}rain
{O}rganization and {C}ortical {E}volution},
journal = {Cerebral cortex},
volume = {31},
number = {11},
issn = {1047-3211},
address = {Oxford},
publisher = {Oxford Univ. Press},
reportid = {FZJ-2022-00970},
pages = {5151 - 5164},
year = {2021},
abstract = {The temporal lobe is implicated in higher cognitive
processes and is one of the regions that underwent
substantial reorganization during primate evolution. Its
functions are instantiated, in part, by the complex layout
of its structural connections. Here, we identified
low-dimensional representations of structural connectivity
variations in human temporal cortex and explored their
microstructural underpinnings and associations to macroscale
function. We identified three eigenmodes which described
gradients in structural connectivity. These gradients
reflected inter-regional variations in cortical
microstructure derived from quantitative magnetic resonance
imaging and postmortem histology. Gradient-informed models
accurately predicted macroscale measures of temporal lobe
function. Furthermore, the identified gradients aligned
closely with established measures of functional
reconfiguration and areal expansion between macaques and
humans, highlighting their potential role in shaping
temporal lobe function throughout primate evolution.
Findings were replicated in several datasets. Our results
provide robust evidence for three axes of structural
connectivity in human temporal cortex with consistent
microstructural underpinnings and contributions to
large-scale brain network function.},
cin = {INM-7},
ddc = {610},
cid = {I:(DE-Juel1)INM-7-20090406},
pnm = {5251 - Multilevel Brain Organization and Variability
(POF4-525)},
pid = {G:(DE-HGF)POF4-5251},
typ = {PUB:(DE-HGF)16},
pubmed = {pmid:34148082},
UT = {WOS:000708798900023},
doi = {10.1093/cercor/bhab149},
url = {https://juser.fz-juelich.de/record/905746},
}