000905766 001__ 905766
000905766 005__ 20220131120341.0
000905766 0247_ $$2Handle$$a2128/30539
000905766 037__ $$aFZJ-2022-00989
000905766 1001_ $$0P:(DE-HGF)0$$aBayrak, Şeyma$$b0$$eCorresponding author
000905766 245__ $$aHeritability of hippocampal functional and microstructural organisation
000905766 260__ $$c2021
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000905766 520__ $$aThe hippocampal formation is an uniquely infolded anatomical structure in the medial temporal lobe and it is involved in a broad range of cognitive and emotional processes. It consists of anatomically and functionally different subfields, including the subiculum (SUB), cornu ammonis areas (CA), and the dentate gyrus (DG). However, despite ample research on learning and plasticity of the hippocampal formation, heritability of its structural and functional organization is not fully known. To answer this question, we extracted microstructurally sensitive neuroimaging (i.e., T1w/T2w ratios) and resting-state functional connectivity information along hippocampal subfield surfaces from a sample of healthy twins and unrelated individuals of the Human Connectome Project Dataset. Our findings robustly demonstrate that functional connectivity and local microstructure of hippocampal subfields are highly heritable. Second, we found marked covariation and genetic correlation between the microstructure of the hippocampal subfields and the isocortex, indicating shared genetic factors influencing the microstructure of the hippocampus and isocortex. In both structural and functional measures, we observed a dissociation of cortical projections across subfields. In sum, our study shows that the functional and structural organization of the hippocampal formation is heritable and has a genetic relation to divergent macroscale functional networks within the isocortex.
000905766 536__ $$0G:(DE-HGF)POF4-5251$$a5251 - Multilevel Brain Organization and Variability (POF4-525)$$cPOF4-525$$fPOF IV$$x0
000905766 7001_ $$aWael, Reinder Vos de$$b1
000905766 7001_ $$aSchaare, H Lina$$b2
000905766 7001_ $$aCaldairou, Benoit$$b3
000905766 7001_ $$aBernasconi, Andrea$$b4
000905766 7001_ $$aBernasconi, Neda$$b5
000905766 7001_ $$aBernhardt, Boris C$$b6
000905766 7001_ $$0P:(DE-Juel1)173843$$aValk, Sofie$$b7$$eCorresponding author$$ufzj
000905766 8564_ $$uhttps://juser.fz-juelich.de/record/905766/files/2021.11.10.468049.full.pdf$$yOpenAccess
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000905766 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)173843$$aForschungszentrum Jülich$$b7$$kFZJ
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000905766 9141_ $$y2021
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000905766 920__ $$lyes
000905766 9201_ $$0I:(DE-Juel1)INM-7-20090406$$kINM-7$$lGehirn & Verhalten$$x0
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