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@ARTICLE{Bayrak:905766,
author = {Bayrak, Şeyma and Wael, Reinder Vos de and Schaare, H Lina
and Caldairou, Benoit and Bernasconi, Andrea and Bernasconi,
Neda and Bernhardt, Boris C and Valk, Sofie},
title = {{H}eritability of hippocampal functional and
microstructural organisation},
reportid = {FZJ-2022-00989},
year = {2021},
abstract = {The hippocampal formation is an uniquely infolded
anatomical structure in the medial temporal lobe and it is
involved in a broad range of cognitive and emotional
processes. It consists of anatomically and functionally
different subfields, including the subiculum (SUB), cornu
ammonis areas (CA), and the dentate gyrus (DG). However,
despite ample research on learning and plasticity of the
hippocampal formation, heritability of its structural and
functional organization is not fully known. To answer this
question, we extracted microstructurally sensitive
neuroimaging (i.e., T1w/T2w ratios) and resting-state
functional connectivity information along hippocampal
subfield surfaces from a sample of healthy twins and
unrelated individuals of the Human Connectome Project
Dataset. Our findings robustly demonstrate that functional
connectivity and local microstructure of hippocampal
subfields are highly heritable. Second, we found marked
covariation and genetic correlation between the
microstructure of the hippocampal subfields and the
isocortex, indicating shared genetic factors influencing the
microstructure of the hippocampus and isocortex. In both
structural and functional measures, we observed a
dissociation of cortical projections across subfields. In
sum, our study shows that the functional and structural
organization of the hippocampal formation is heritable and
has a genetic relation to divergent macroscale functional
networks within the isocortex.},
cin = {INM-7},
cid = {I:(DE-Juel1)INM-7-20090406},
pnm = {5251 - Multilevel Brain Organization and Variability
(POF4-525)},
pid = {G:(DE-HGF)POF4-5251},
typ = {PUB:(DE-HGF)25},
url = {https://juser.fz-juelich.de/record/905766},
}