000905767 001__ 905767
000905767 005__ 20220131120341.0
000905767 0247_ $$2Handle$$a2128/30424
000905767 037__ $$aFZJ-2022-00990
000905767 1001_ $$0P:(DE-Juel1)188407$$aWan, Bin$$b0$$eCorresponding author
000905767 245__ $$aAsymmetry of cortical functional hierarchy in humans and macaques suggests phylogenetic conservation and adaptation
000905767 260__ $$c2021
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000905767 520__ $$aThe human cerebral cortex is symmetrically organized along large-scale axes but also presents inter-hemispheric differences in structure and function. The quantified contralateral homologous difference, i.e., asymmetry, is a key feature of the human brain left-right axis supporting functional processes, such as language. Here, we assessed whether the asymmetry of cortical functional organization is heritable and phylogenetically conserved between humans and macaques. Our findings indicate asymmetric organization along an axis describing a hierarchical functional trajectory from perceptual/action to abstract cognition. Whereas language network showed leftward asymmetric organization, frontoparietal network showed rightward asymmetric organization. These asymmetries were heritable and comparable between humans and macaques, suggesting (phylo)genetic conservation. However, both language and frontoparietal networks showed a qualitatively larger asymmetry in humans relative to macaques and variable heritability in humans. This may reflect an evolutionary adaptation allowing for experience-dependent specialization, linked to higher-order cognitive functions uniquely developed in humans.
000905767 536__ $$0G:(DE-HGF)POF4-5251$$a5251 - Multilevel Brain Organization and Variability (POF4-525)$$cPOF4-525$$fPOF IV$$x0
000905767 7001_ $$0P:(DE-HGF)0$$aBayrak, Şeyma$$b1
000905767 7001_ $$0P:(DE-HGF)0$$aXu, Ting$$b2
000905767 7001_ $$0P:(DE-HGF)0$$aSchaare, H Lina$$b3
000905767 7001_ $$0P:(DE-HGF)0$$aBethlehem, Richard AI$$b4
000905767 7001_ $$0P:(DE-HGF)0$$aBernhardt, Boris C$$b5
000905767 7001_ $$0P:(DE-Juel1)173843$$aValk, Sofie$$b6$$eCorresponding author
000905767 8564_ $$uhttps://juser.fz-juelich.de/record/905767/files/2021.11.03.466058.full.pdf$$yOpenAccess
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000905767 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)188407$$aForschungszentrum Jülich$$b0$$kFZJ
000905767 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)173843$$aForschungszentrum Jülich$$b6$$kFZJ
000905767 9131_ $$0G:(DE-HGF)POF4-525$$1G:(DE-HGF)POF4-520$$2G:(DE-HGF)POF4-500$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$9G:(DE-HGF)POF4-5251$$aDE-HGF$$bKey Technologies$$lNatural, Artificial and Cognitive Information Processing$$vDecoding Brain Organization and Dysfunction$$x0
000905767 9141_ $$y2021
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000905767 915__ $$0LIC:(DE-HGF)CCBYNCND4$$2HGFVOC$$aCreative Commons Attribution-NonCommercial-NoDerivs CC BY-NC-ND 4.0
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000905767 9201_ $$0I:(DE-Juel1)INM-7-20090406$$kINM-7$$lGehirn & Verhalten$$x0
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