000905768 001__ 905768
000905768 005__ 20220131120342.0
000905768 0247_ $$2Handle$$a2128/30500
000905768 037__ $$aFZJ-2022-00991
000905768 1001_ $$0P:(DE-HGF)0$$aPark, Bo-yong$$b0$$eCorresponding author
000905768 245__ $$aMultilevel neural gradients reflect transdiagnostic effects of major psychiatric conditions on cortical morphology
000905768 260__ $$c2021
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000905768 520__ $$aIt is increasingly recognized that multiple psychiatric conditions are underpinned by shared neural pathways, affecting similar brain systems. Here, we assessed i) shared dimensions of alterations in cortical morphology across six major psychiatric conditions (autism spectrum disorder, attention deficit/hyperactivity disorder, major depression, obsessive-compulsive disorder, bipolar disorder, schizophrenia) and ii) carried out a multiscale neural contextualization, by cross-referencing shared anomalies against cortical myeloarchitecture and cytoarchitecture, as well as connectome and neurotransmitter organization. Pooling disease-related effects on MRI-based cortical thickness measures across six ENIGMA working groups, including a total of 28,546 participants (12,876 patients and 15,670 controls), we computed a shared disease dimension on cortical morphology using principal component analysis that described a sensory-fugal pattern with paralimbic regions showing the most consistent abnormalities across conditions. The shared disease dimension was closely related to cortical gradients of microstructure and intrinsic connectivity, as well as neurotransmitter systems, specifically serotonin and dopamine. Our findings embed the shared effects of major psychiatric conditions on brain structure in multiple scales of brain organization and may provide novel insights into neural mechanisms into transdiagnostic vulnerability.
000905768 536__ $$0G:(DE-HGF)POF4-5251$$a5251 - Multilevel Brain Organization and Variability (POF4-525)$$cPOF4-525$$fPOF IV$$x0
000905768 7001_ $$aKebets, Valeria$$b1
000905768 7001_ $$aLarivière, Sara$$b2
000905768 7001_ $$0P:(DE-Juel1)187157$$aHettwer, Meike D$$b3$$ufzj
000905768 7001_ $$0P:(DE-Juel1)187055$$aPaquola, Casey$$b4$$ufzj
000905768 7001_ $$aRooij, Daan van$$b5
000905768 7001_ $$aBuitelaar, Jan$$b6
000905768 7001_ $$aFranke, Barbara$$b7
000905768 7001_ $$aHoogman, Martine$$b8
000905768 7001_ $$aSchmaal, Lianne$$b9
000905768 7001_ $$aVeltman, Dick J$$b10
000905768 7001_ $$aHeuvel, Odile van den$$b11
000905768 7001_ $$aStein, Dan J$$b12
000905768 7001_ $$aAndreassen, Ole A$$b13
000905768 7001_ $$aChing, Christopher RK$$b14
000905768 7001_ $$aTurner, Jessica$$b15
000905768 7001_ $$aErp, Theo GM van$$b16
000905768 7001_ $$aEvans, Alan C$$b17
000905768 7001_ $$aDagher, Alain$$b18
000905768 7001_ $$aThomopoulos, Sophia I$$b19
000905768 7001_ $$aThompson, Paul M$$b20
000905768 7001_ $$0P:(DE-Juel1)173843$$aValk, Sofie L$$b21$$ufzj
000905768 7001_ $$aKirschner, Matthias$$b22
000905768 7001_ $$aBernhardt, Boris C$$b23
000905768 8564_ $$uhttps://juser.fz-juelich.de/record/905768/files/2021.10.29.466434v1.full.pdf$$yOpenAccess
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000905768 9141_ $$y2021
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